183866-61-7 Usage
Description
1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-5-(1-hydroxyethyl)-, phenylmethyl ester, (R)is an organic compound with the molecular formula C18H19NO3. It is the (R)-enantiomer of the drug levocetirizine, which is a non-sedating antihistamine used to treat allergies, hay fever, and chronic hives. 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-5-(1-hydroxyethyl)-,
phenylmethyl ester, (R)is an ester derivative of pyridinecarboxylic acid, featuring a phenylmethyl group attached to the carboxylic acid moiety. The (R)-enantiomer designation indicates the specific arrangement of the functional groups around the chiral center of the molecule, which is crucial for its pharmacological activity.
Uses
Used in Pharmaceutical Industry:
1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-5-(1-hydroxyethyl)-, phenylmethyl ester, (R)is used as an active pharmaceutical ingredient for the development of non-sedating antihistamines. Its application is primarily for the treatment of allergies, hay fever, and chronic hives, providing relief from symptoms such as itching, sneezing, and runny nose.
Used in Research and Development:
In the field of research and development, 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-5-(1-hydroxyethyl)-, phenylmethyl ester, (R)serves as a valuable compound for studying the effects of enantiomers on pharmacological activity. This knowledge can be applied to the development of more effective and safer drugs, as well as understanding the role of chirality in drug design and action.
Used in Drug Synthesis:
1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-5-(1-hydroxyethyl)-, phenylmethyl ester, (R)is also used as a key intermediate in the synthesis of other related pharmaceutical compounds. Its unique structure and functional groups make it a versatile building block for creating new drugs with potential applications in various therapeutic areas.
Check Digit Verification of cas no
The CAS Registry Mumber 183866-61-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,8,6 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 183866-61:
(8*1)+(7*8)+(6*3)+(5*8)+(4*6)+(3*6)+(2*6)+(1*1)=177
177 % 10 = 7
So 183866-61-7 is a valid CAS Registry Number.
183866-61-7Relevant articles and documents
Total syntheses of the Strychnos indole alkaloids (-)-tubifoline, (-)-tubifolidine, and (-)-19,20-dihydroakuammicine
Amat, Mercedes,Coll, M.-Dolors,Bosch, Joan,Espinosa, Enric,Molins, Elies
, p. 935 - 948 (2007/10/03)
Two different strategies for the synthesis of pentacyclic Strychnos alkaloids in enantiomerically pure form are explored. Both of them involve the use of enantiopure 2-(4-piperidylmethyl)indoles prepared by kinetic resolution of 1-(3-pyridyl)ethanol, followed by partial reduction of the pyridine ring to the tetrahydropyridine level, Claisen rearrangement of the resulting allylic alcohol, and finally Smith indolization. Whereas 2-(4-piperidylmethyl)indole 6 could not be converted to tetracyclic ABDE substructures of Strychnas alkaloids, photocyclization of chloroacetamide 14, derived from (piperidylmethyl)indole 13, satisfactorily afforded the stemmadenine-type tetracycle 15, which was then converted to the alkaloids (-)-tubifoline, (-)-tubifolidine, and (-19,20-dihydroakuammicine.
