183989-82-4

Basic information

• Product Name: N-(4-cyano-2-iodophenyl)-2,2,2-trifluoroacetamide
• Synonyms: N-(4-cyano-2-iodophenyl)-2,2,2-trifluoroacetamide
• CAS NO: 183989-82-4
• Molecular Weight: 340.043
• Mol File: 183989-82-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(4-cyano-2-iodophenyl)-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-cyano-2-iodophenyl)-2,2,2-trifluoroacetamide(183989-82-4)
• EPA Substance Registry System: N-(4-cyano-2-iodophenyl)-2,2,2-trifluoroacetamide(183989-82-4)

Safety Data

• Hazardous Substances Data: 183989-82-4(Hazardous Substances Data)

Upstream product

• 33348-34-4 4-amino-3-iodobenzonitrile 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1192152-65-0 2-(trifluoromethyl)-1H-indole-5-carbonitrile 
• 1612234-04-4 2',4'-dioxo-1-tosyl-2',4'-dihydro-1'H-spiro[indoline-3,3'-quinoline]-6'-carbonitrile 

Relevant articles and documents

Regio- and chemoselective n-1 acylation of indoles: Pd-catalyzed domino cyclization to afford 1,2-fused tricyclic indole scaffolds

A concise method for the synthesis of 1,2-fused tricyclic indole scaffolds by domino cyclization involving a Pd-catalyzed Sonogashira coupling, indole cyclization, regio- and chemoselective N-1 acylation, and 1,4-Michael addition is reported. This method

INDOLE AND AZAINDOLE MODULATORS OF THE ALPHA 7 NACHR

This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Synthesis of indoles and quinolones by sequential Wittig and Heck reactions

Trifluoroacetamido derivatives 18a-c and 19a-c react with phosphorane 2 in boiling toluene to give the corresponding enamines 12a-c and 13a-c respectively which are precursors of the trifluoromethylated indoles 14a-c and quinolones 15a-c.