183991-46-0Relevant articles and documents
Synthesis of new sulfonyloximes and their use in free-radical olefin carbo-oximation
Ovadia, Benjamin,Robert, Frédéric,Landais, Yannick
, p. 1958 - 1961 (2015)
New bifunctional reagents for free-radical carbo-oximation of olefins have been developed. In this process, a single reagent can act both as a trap for nucleophilic radicals as well as a source of electrophilic radical via an α-scission of an alkylsulfonyl radical. This strategy involving the addition of a C-centered electrophilic radical and an oxime across the double bond of an electron-rich alkene is initiated with a t-BuO radical following an unusual mechanism, supported by both experiments and density functional theory calculations.
GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
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Page/Page column 69, (2013/09/12)
The present invention provides gonadotropin releasing hormone receptor antagonists and the pharmaceutical composition comprising the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease
Synthesis and antimicrobial activities of novel peptide deformylase inhibitors
Yin, Ling,Xu, Wei-Ren,Wang, Zhi-Guo,Zhang, Da-Tong,Jia, Jiong,Ge, Yan-Qing,Li, Yan,Wang, Jian-Wu
experimental part, p. 196 - 205 (2010/10/19)
A new series of N-formylhydroxylamine compounds were designed, optimized with the AutoDock 4.0.1to investigate the interactions between the target compounds and the amino acid residues of the Escherichia coli PDF?Ni enzyme, and then synthesized through mu