184006-60-8 Usage
Description
Clenbuterol-D9 HCl is a deuterated internal standard used for the quantification of clenbuterol in biological samples. It is a chemically modified version of the bronchodilator clenbuterol, with a deuterium atom incorporated at the 9th position, which aids in the accurate measurement and analysis of clenbuterol levels in various biological matrices.
Used in Pharmaceutical Industry:
Clenbuterol-D9 HCl is used as an internal standard for the quantification of clenbuterol in biological samples by ultra-high pressure liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). This application is crucial for ensuring the accuracy and reliability of clenbuterol measurements, which is essential for monitoring its therapeutic use and detecting potential abuse in sports and other settings.
Check Digit Verification of cas no
The CAS Registry Mumber 184006-60-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,0,0 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 184006-60:
(8*1)+(7*8)+(6*4)+(5*0)+(4*0)+(3*6)+(2*6)+(1*0)=118
118 % 10 = 8
So 184006-60-8 is a valid CAS Registry Number.
184006-60-8Relevant articles and documents
Synthetic method of deuterium-labeled D9-clenbuterol hydrochloride
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Paragraph 0015; 0050-0051, (2019/01/14)
The invention belongs to the field of food safety and standard substance synthesis, and discloses a synthetic method of deuterium-labeled D9-clenbuterol hydrochloride. According to the method, 4-amino-3,5-dichloroacetophenone is taken as a raw material and subjected to three-step reaction including bromination, D9 tert-butyl amination and reduction, and deuterium-labeled D9-clenbuterol hydrochloride is generated. The method is simple to operate, reaction conditions are mild (most reactions are performed at room temperature), reaction routes are reasonable, the process is advanced, the processing method is simple, and a product is easy to purify. Meanwhile, the total conversion rate of D9-tert-butylamine as the core raw material in the synthesis process of D9-clenbuterol hydrochloride is increased to 40% from 4.2%, yield is increased to 64%, and the method has good economic value and social value.