184015-01-8

Basic information

• Product Name: Imidazo[1,2-b]pyridazine, 2-(4-methylphenyl)-6-propoxy-
• CAS NO: 184015-01-8
• Molecular Formula: C16H17N3O
• Molecular Weight: 267.33
• Mol File: 184015-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-b]pyridazine, 2-(4-methylphenyl)-6-propoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-b]pyridazine, 2-(4-methylphenyl)-6-propoxy-(184015-01-8)
• EPA Substance Registry System: Imidazo[1,2-b]pyridazine, 2-(4-methylphenyl)-6-propoxy-(184015-01-8)

Safety Data

• Hazardous Substances Data: 184015-01-8(Hazardous Substances Data)

Upstream product

• 619-41-0 4-(bromoacetyl)toluene 
• 90008-50-7 3-amino-6-propoxypyridazine 

Relevant articles and documents

Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazopyridazines as new ligands for the benzodiazepine receptor

A series of 2,3-disubstituted-6-alkoxyimidazopyridazines has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazopyridazines were found to be the most potent BZR ligands (eg, 4a, IC50 7 nM; 4e, IC50 14 nM; 4v, IC50 8 nM).Imidazopyridazines unsubstituted in the 3-position, or containing bulkier alkoxy groups in the 6-position, were found to bind less strongly to the BZR.Selected compounds from the series wereidentified from in vitro GABA-shift experiments as BZR agonists.Molecular modelling has been employed to identify the common pharmacophoric points of lipophilic and hydrogen bonding, ligand-receptor interaction and areas of steric hindrance for these substituted imidazopyridazines at the BZR. - Keywords: imidazopyridazine; benzodiazepine receptor; structure-activity relationship; molecullar modelling