184025-19-2 Usage
Description
Ciproxifan is a histamine H3 receptor antagonist with high selectivity and potency, characterized by its ability to inhibit histamine release in rat synaptosomal preparations (Ki = 0.5 nM). It demonstrates selectivity for histamine H3 over other receptors such as histamine H1 and H2, M3 muscarinic, and various adrenergic and serotonin receptors. Ciproxifan's actions on histamine levels in the brain make it a promising candidate for the treatment of sleep and neurological disorders.
Uses
Used in Pharmaceutical Industry:
Ciproxifan is used as a histamine H3 receptor antagonist for the treatment of sleep and neurological disorders. Its ability to modulate histamine levels in the brain offers potential therapeutic benefits in managing these conditions.
In Sleep Disorder Treatment:
Ciproxifan is used as a therapeutic agent for sleep disorders, where it helps increase wake episode duration and latency to fall asleep, as demonstrated in rats when administered at a dose of 2 mg/kg.
In Neurological Disorder Treatment:
Ciproxifan is utilized as a treatment for neurological disorders, potentially offering benefits through its modulation of histamine levels in the brain, which can impact various neurological functions and conditions.
Biochem/physiol Actions
Potent, selective H3 histamine receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 184025-19-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,0,2 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 184025-19:
(8*1)+(7*8)+(6*4)+(5*0)+(4*2)+(3*5)+(2*1)+(1*9)=122
122 % 10 = 2
So 184025-19-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
