18403-22-0

Basic information

• Product Name: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol
• Synonyms: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol
• CAS NO: 18403-22-0
• Molecular Weight: 280.321
• Mol File: 18403-22-0.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol(18403-22-0)
• EPA Substance Registry System: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol(18403-22-0)

Safety Data

• Hazardous Substances Data: 18403-22-0(Hazardous Substances Data)

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 77-76-9 2,2-dimethoxy-propane 
• 7473-38-3 benzyl β-L-arabinopyranoside 
• 100-51-6 benzyl alcohol 
• 7296-56-2 β-L-arabinopyranose 
• 5328-37-0 L-arabinose 
• 7296-55-1 L-arabinose 
• 87-72-9 L-(+)-arabinose 
• 116-11-0 2-Methoxypropene 
• 67-64-1 acetone 

Downstream Products

• 18402-79-4 Benzyl 2-O-benzoyl-β-L-arabinopyranoside 
• 550346-08-2 benzyl 2-O-benzoyl-3,4-O-benzylidene-β-L-arabinopyranoside 
• 550346-09-3 C₂₆H₂₄O₇ 
• 22900-10-3 (4R,5S)-tetrahydro-2H-pyran-2,4,5-triol 
• 136737-25-2 benzyl 2-deoxy-3,4-O-isopropylidene-β-L-erythro-pentopyranoside 
• 432492-86-9 N-(6-benzyloxy-2,2-dimethyldihydro-[1,3]dioxolo[4,5-c]pyran-7-ylidene)-N'-(4-toluenesulfonyl)hydrazine 
• 171866-28-7 1-O-methyl-2,3,5-tri-O-benzoyl-L-ribofuranose 
• 3080-30-6 1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose 
• 87-72-9 L-ribose 
• 171866-29-8 1-bromo-2-deoxy-2-β-fluoro-3,5-di-O-benzoyl-α-L-arabinose 
• 171866-30-1 1,3,5-Tri-O-benzoyl-α-L-ribofuranose 
• 171721-00-9 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-L-arabinofuranose 
• 171720-99-3 1,3,5-tri-O-benzoyl-2-O-(2-imidazolylsulfonyl)-α-L-ribofuranose 
• 163252-36-6 clevudine 

Relevant articles and documents

BIARYL AMIDES WITH MODIFIED SUGAR GROUPS FOR TREATMENT OF DISEASES ASSOCIATED WITH HEAT SHOCK PROTEIN PATHWAY

Provided are biaryl amides and coumarin-based compounds with modified sugar groups for treatment of diseases associated with heat shock protein pathway. The compounds having the following formulas, wherein variables are as defined herein. Formulae (I), (II), (III), (IV), and (V), Pharmaceutical compositions of the compounds are also provided. These biaryl amides and coumarin-based derivatives with modified sugar groups are useful for treatment and prevention of diseases and disorders, including neurological disorders, such as neurodegenerative diseases and nerve damaging disorders, for example, diabetic peripheral neuropathy.

Hafnium trifluoromethanesulfonate catalyzed silyl ether protecting group removing method

The invention provides a hafnium trifluoromethanesulfonate catalyzed silyl ether protecting group removing method. Various silyl ether protecting groups of nearly 50 kinds of substrates can be efficiently removed in 0.5-16 hours at room temperature by taking 0.02mol%-0.3mol% hafnium trifluoromethanesulfonate as a catalyst, a silyl ether protected hydroxyl compound as a substrate and conventional AR methanol as a solvent. 42 kinds of silyl ether protecting group removing products can be obtained at high yield by performing conventional slica column chromatography purification on a crude product. By regulating the use amount of the catalyst, the Hf(OTf)4 catalyst can realize regioselective removal of 1-degree, 2-degree and 3-degree alkyl TBS and aryl TBS protective groups. Moreover, in a proper equivalent scope, the Hf(OTf)4 catalyst can also realize 1) chemoselective removal of different kinds of silica-based protective groups; and 2) chemoselective removal of 1-degree TBS protective groups under the condition of not affecting a majority of common hydroxyl protective groups.

Regioselective ring opening of exo- and endo-3,4-benzylidene acetals of arabinopyranoside derivatives with Lewis acids and reducing agents

Dioxolane type 3,4-benzylidene acetals of benzyl β-l-arabinose either as a mixture or pure exo- and endo-isomers cleavaged with BF3· OEt2/Et3SiH in dichloromethane or acetonitrile regioselectively, provided the 4-O-benzyl-