184040-74-2

Basic information

• Product Name: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-
• Synonyms: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-;3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylic acid;3-[[(4-Chloro-3-methyl-5-isoxazolyl)amino]sulfonyl]-2-thiophenecarboxylic acid
• CAS NO: 184040-74-2
• Molecular Formula: C₉H₇ClN₂O₅S₂
• Molecular Weight: 322.74528
• Mol File: 184040-74-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 556.983°C at 760 mmHg
• Flash Point: 290.653°C
• Appearance: /
• Density: 1.746±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-(184040-74-2)
• EPA Substance Registry System: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-(184040-74-2)

Safety Data

• Hazardous Substances Data: 184040-74-2(Hazardous Substances Data)

Usage

General Description

2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl]- is a chemical compound with potential pharmaceutical and agricultural applications. It is a sulfonamide compound that contains a thiophene ring and a carboxylic acid group. The presence of the isoxazolyl and chloro-methyl groups in the molecule suggests that it may have antimicrobial or herbicidal properties. Additionally, the presence of the sulfonamide group suggests that it may have potential use as a pharmaceutical drug, possibly as an antibacterial agent. Further research and testing are necessary to fully understand the potential uses and effects of this compound.

InChI:InChI=1/C9H7ClN2O5S2/c1-4-6(10)8(17-11-4)12-19(15,16)5-2-3-18-7(5)9(13)14/h2-3,12H,1H3,(H,13,14)

Upstream product

• 184644-72-2 3-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxylic acid methyl ester 
• 59337-92-7 2-(carbomethoxy)thiophene-3-sulfonyl chloride 

Downstream Products

• 205515-56-6 N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide 
• 205515-55-5 N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-acetoxymethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide 
• 215501-60-3 N-(4-chloro-3-methyl-5-isoxazolyl)-2-(2-(3-methoxy-2,4,6-trimethylphenyl)acetyl)-3-thiophenesulfonamide 
• 184036-04-2 N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(4,5-dimethoxy-2-methoxycarbonylphenyl)aminocarbonyl]thiophene-3-sulfonamide 
• 184036-18-8 N-(4-chloro-3-methyl-5-isoxazolyl)-2-{[2-cyano-4,5-(methylenedioxy)phenyl]aminocarbonyl}thiophene-3-sulfonamide 

Relevant articles and documents

2-aryloxycarbonylthiophene-3-sulfonamides highly potent and ET(A) selective endothelin receptor antagonists

A series of 2-aryloxycarbonylthiophene-3-sulfonamides were synthesized and evaluated to determine their antagonistic activity at the endothelin receptors. N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(3,4-methylenedioxy) phenoxycarbonyl]thiophene-3-sulfonamide was identified as a highly selective, potent (IC50= 8.3 nM) and low molecular weight nonpeptide antagonist.

SUBSTITUTED THIOPHENES

Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

Sulfonamides and derivatives thereof that modulate the activity of endothelin

Thienyl-, furyl-, pyrrolyl- and phenylsulfonamides, formulations of pharmaceutically-acceptable derivatives thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienyl