18420-41-2

Basic information

• Product Name: 2-(CHLOROMETHYL)TETRAHYDROPYRAN
• Synonyms: 2-(CHLOROMETHYL)TETRAHYDRO-2H-PYRAN;2-(CHLOROMETHYL)TETRAHYDROPYRAN;AKOS BBS-00003971;TETRAHYDROPYRAN-2-METHYL CHLORIDE;TETRAHYDROPYRAN-2-METHYLENE-CHLORIDE;2-(chloromethyl)tetrahydro-2h-pyra;(2-Tetrahydropyranyl)methyl chloride;2-(Chloromethyl)tetrahydro-(2H)-pyrane
• CAS NO: 18420-41-2
• Molecular Formula: C₆H₁₁ClO
• Molecular Weight: 134.6
• Product Categories: Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrans;PyransHeterocyclic Building Blocks
• Mol File: 18420-41-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 53-54 °C12 mm Hg(lit.)
• Flash Point: 131 °F
• Appearance: /
• Density: 1.075 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.35mmHg at 25°C
• Refractive Index: n20/D 1.462(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Difficult to mix.
• BRN: 102996
• CAS DataBase Reference: 2-(CHLOROMETHYL)TETRAHYDROPYRAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)TETRAHYDROPYRAN(18420-41-2)
• EPA Substance Registry System: 2-(CHLOROMETHYL)TETRAHYDROPYRAN(18420-41-2)

Safety Data

• Hazard Codes: Xi,C
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 18420-41-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 18420-41-2 differently. You can refer to the following data:
1. 2-(Chloromethyl)tetrahydro-2H-pyran is a useful reagent for organic synthesis studies and in chemical industry.
2. 2-(Chloromethyl)tetrahydro-2H-pyran may be used in chemical synthesis studies.

InChI:InChI=1/C6H11ClO/c7-5-6-3-1-2-4-8-6/h6H,1-5H2

Upstream product

• 100-72-1 Tetrahydropyran-2-methanol 
• 86692-87-7 hex-5-enyl hydroperoxide 
• 821-41-0 5-Hexen-1-ol 
• 64818-36-6 5-hexenyl methanesulfonate 
• 100-73-2 acrolein dimer 

Downstream Products

• 821-41-0 5-Hexen-1-ol 
• 928-90-5 5-hexyl-1-ol 
• 135492-09-0 Diphenyl(tetrahydropyranyl-2-methyl)phosphan 
• 135492-10-3 Dicyclohexyl(tetrahydropyranyl-2-methyl)phosphan 
• 1720-37-2 2-(hex-5-yn-1-yloxy)tetrahydro-2H-pyran 
• 58944-42-6 hept-5-yn-1-ol 
• 77758-51-1 methyl hex-5-ynoate 
• 53293-00-8 hex-5-ynoic acid 
• 156379-75-8 (Z)-8-Oxo-9-(triphenyl-λ⁵-phosphanylidene)-non-5-enoic acid methyl ester 
• 96790-36-2 (8R)-trioxilin A3 
• 96790-36-2 (8S)-trioxilin A3 
• 180-84-7 1,7-dioxaspiro[5.5]undecane 
• 83015-88-7 1,6-Dioxaspiro<4.5>decan-2-methanol 
• 37011-86-2 tetrahydro-2-(6-heptynyloxy)-2H-pyran 

Relevant articles and documents

Chemoenzymatic Halocyclization of γ,δ-Unsaturated Carboxylic Acids and Alcohols

A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using the robust V-dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent performance of the biocatalyst.

Synthesis and solid-state polymerization of a macrocyclic compound with two butadiyne units

A macrocyclic compound 1 with two butadiyne and four dodecyloxy-substituted benzamide moieties was successfully synthesized, and its ring structure was confirmed by the MALDI-TOF mass spectra and the 1HNMR spectra. Compound 1 showed two modifications depending on solvent for the solidification. Characteristic excitonic absorption bands of polydiacetylene were observed at around 500 nm for one of the modifications after UV irradiation. Quantitative conversion of butadiyne moieties to the corresponding polydiacetylene structure was confirmed by the Raman spectra.

Efficient synthesis of 8,11-dimethylene-bicyclo[5.3.1]undecan-2-one

We report here, an effective methodology for the preparation of 8,11-dimethylene-bicyclo[5.3.1]undecan-2-one. The key steps in these reactions were chloromethylation, cationic-alkyne cyclization and anionic fragmentation sequence.