184292-93-1Relevant articles and documents
Synthesis and biological activity of enantiomeric pairs of 5-(alk-2-enyl)thiolactomycin and 5-[(E)-cycloalk-2-enylidenemethyl] thiolactomycin congeners
Ohata, Kohei,Terashima, Shiro
experimental part, p. 920 - 936 (2010/03/23)
The title compounds were synthesized by the efficient route previously explored for the synthesis of enantiomeric pairs of thiolactomycin and its 3-demethyl derivative. These studies were carried out to prove the flexibility of the previously explored synthetic route to natural thiolactomycin (TLM) 1 and to examine the structure-activity relationship on the 5-position of 1. While all of the synthesized congeners lacked in vitro antibacterial activity, these studies led us to find 5-(alk-2-enyl)-TLM (ent-4d) which exhibits mammalian type I fatty acid synthase (FAS) inhibitory activity equal to that of C75, a potent inhibitor reported previously. It was also found that 5-[(E)-cycloalk-2- enylidenemethyl]-TLM (ent-5c) exhibited slightly less potent mammalian type I FAS inhibitory activity than C75.
2-OXAZOLIDINONES AND THEIR USE AS INHIBITORS OF ANIMAL CELL MOTILITY AND GROWTH
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Page 53; 67, (2010/11/30)
Cell motility and growth inhibitors, including compounds of the general structural formula (I), and use of the cell motility and cell growth inhibitors, and pharmaceutically acceptable salts, pro-drugs, and solvates thereof, as therapeutic agents, are disclosed.
Synthesis of β,γ-unsaturated N-acyl-2-oxazolidinones
Dobarro, Alicia,Velasco, Dolores
, p. 13525 - 13530 (2007/10/03)
An effective imide formation method is presented, which allows the preparation of β,γ-unsaturated N-acyl-2-oxazolidinones with high yields and without isomerization of the double bond to give the α,γ-unsaturated isomers, which are the inevitable by-products when alternative procedures are used.
