184534-53-0

Basic information

• Product Name: 1H-Pyrazol-5-ol, 4-(1H-indol-3-ylphenylmethyl)-3-methyl-1-phenyl-
• CAS NO: 184534-53-0
• Molecular Formula: C25H21N3O
• Molecular Weight: 379.461
• Mol File: 184534-53-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazol-5-ol, 4-(1H-indol-3-ylphenylmethyl)-3-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazol-5-ol, 4-(1H-indol-3-ylphenylmethyl)-3-methyl-1-phenyl-(184534-53-0)
• EPA Substance Registry System: 1H-Pyrazol-5-ol, 4-(1H-indol-3-ylphenylmethyl)-3-methyl-1-phenyl-(184534-53-0)

Safety Data

• Hazardous Substances Data: 184534-53-0(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 130691-00-8 (4E)-4-benzylidene-5-methyl-2-phenyl-3,4-dihydropyrazol-3(3H)-one 
• 100-52-7 benzaldehyde 
• 89-25-8 edaravone 
• 23901-60-2 4-benzylidene-3-methyl-1-phenylpyrazolone 

Downstream Products

• 130691-00-8 (4E)-4-benzylidene-5-methyl-2-phenyl-3,4-dihydropyrazol-3(3H)-one 

Relevant articles and documents

Solid-state synthesis of 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5- pyrazolones by catalysis of molecular iodine

4-[(Indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones could be smoothly and effectively obtained in good yields through the iodine-catalyzed reactions under solid-state conditions at room tempertaure. The three-component approach in a one-pot proced

The Solid-State Michael Addition of 3-Methyl-1-phenyl-5-pyrazolone

A novel solid-state Michael addition between pyrazolone 1 and 4-arylidenepyrazolones 2 at ambient temperature produced Michael adducts, 4,4′-arylidenebis(3-methyl-1-phenyl-5-pyrazolones) 3. Pyrazolones 3 formed salts 4 with Cu2+ in solution, indicating the enolic structure of the pyrazolone rings. The reactivity of 2 with 1 is discussed in terms of the electronic and steric effects of the substituent on the arylidene group of compounds 2. Pyrazolone 1 also underwent the solid state Michael addition reaction with maleimide at 100° to give the adducts 7, 8 and 9.