18466-51-8 Usage
Description
PELARGONIDIN-3-GLUCOSIDE CHLORIDE, also known as Pelargonidin 3-O-β-glucopyranoside, is a naturally occurring anthocyanin derived from strawberries and other fruits and flowers. It is characterized by its certified chromatographic purity and is soluble in water, ethanol, and methanol. PELARGONIDIN-3-GLUCOSIDE CHLORIDE possesses potential anti-inflammatory, anti-adhesive, anti-estrogenic, and angiotensin-converting enzyme inhibitory activities, making it a promising candidate for various applications in the pharmaceutical and food industries.
Uses
Used in Pharmaceutical Applications:
PELARGONIDIN-3-GLUCOSIDE CHLORIDE is used as a potential therapeutic agent for its anti-inflammatory, anti-adhesive, and anti-estrogenic properties. It is particularly valuable for its angiotensin-converting enzyme inhibitory activity, which can contribute to the development of treatments for various health conditions.
Used in Anticancer Applications:
PELARGONIDIN-3-GLUCOSIDE CHLORIDE is used as an anticancer agent, as it has been identified as the glucoside of Pelargonidin (P218500), a potential antidiabetic agent. Its presence in strawberries and other fruits may also contribute to the overall health benefits of these foods, particularly in cancer prevention and treatment.
Used in Food Industry:
PELARGONIDIN-3-GLUCOSIDE CHLORIDE is used as a natural colorant in the food industry due to its vibrant hue and presence in various fruits and flowers. Its water solubility makes it an ideal choice for adding color to a wide range of products, from beverages to confectionery items.
Used in Cosmetics Industry:
PELARGONIDIN-3-GLUCOSIDE CHLORIDE is used as an ingredient in the cosmetics industry for its potential anti-inflammatory and anti-adhesive properties. These characteristics can be beneficial in the development of skincare products aimed at reducing inflammation and promoting a healthy skin barrier.
Biochem/physiol Actions
Callistephin chloride is an anthocyanin which can be found in berries, for example in strawberries and chokeberries. Is has antioxidant activity and is examined for its neuroprotective properties.
Check Digit Verification of cas no
The CAS Registry Mumber 18466-51-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,4,6 and 6 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 18466-51:
(7*1)+(6*8)+(5*4)+(4*6)+(3*6)+(2*5)+(1*1)=128
128 % 10 = 8
So 18466-51-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H20O10.ClH/c22-8-16-17(26)18(27)19(28)21(31-16)30-15-7-12-13(25)5-11(24)6-14(12)29-20(15)9-1-3-10(23)4-2-9;/h1-7,16-19,21-22,26-28H,8H2,(H2-,23,24,25);1H/t16-,17-,18+,19-,21-;/m1./s1
18466-51-8Relevant articles and documents
Functional characterization of a UDP-glucose:flavonoid 3-O- glucosyltransferase from the seed coat of black soybean (Glycine max (L.) Merr.)
Kovinich, Nik,Saleem, Ammar,Arnason, John T.,Miki, Brian
experimental part, p. 1253 - 1263 (2011/04/22)
The seed coats of black soybean (Glycine max (L.) Merr.) accumulate red (cyanidin-), blue (delphinidin-), purple (petunidin-), and orange (pelargonidin-based) anthocyanins almost exclusively as 3-O-glucosides; however, the responsible enzyme has not been identified. In this study, the full-length cDNA which encodes the enzyme that catalyzes the final step in anthocyanin biosynthesis, namely UDP-glucose:flavonoid 3-O-glucosyltransferase (UGT78K1), was isolated from the seed coat tissue of black soybean using rapid amplification of cDNA ends (RACE). Of the 28 flavonoid substrates tested, the purified recombinant protein glucosylated only anthocyanidins and flavonols, and demonstrated strict 3-OH regiospecificity. Galactose could also be transferred with relatively low activity to the 3-position of cyanidin or delphinidin in vitro. These findings are consistent with previous reports of mainly 3-O-glucosylated and minor amounts of 3-O-galactosylated anthocyanins in the seed coat of black soybean. The recombinant enzyme exhibited pronounced substrate inhibition by cyanidin at 100 μM acceptor concentration. Transfer of UGT78K1 into the Arabidopsis T-DNA mutant (ugt78d2) deficient in anthocyanidin and flavonol 3-O-glucosyltransferase activity, restored the accumulation of anthocyanins and flavonols, suggesting the in vivo function of the enzyme as a flavonoid 3-O-glucosyltransferase. Genomic and phylogenetic analyses suggest the existence of three additional soybean sequences with high similarity to UGT78K1. RT-PCR confirmed the co-expression of one of these genes (Glyma08g07130) with UGT78K1 in the seed coat of black soybean, suggesting possible functional redundancies in anthocyanin biosynthesis in this tissue.
