18474-60-7 Usage
Description
4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID is an organic compound with the molecular formula C9H5Cl2NO2. It is characterized by the presence of a chlorine atom at the 4th and 6th positions of the indole ring, and a carboxylic acid group at the 2nd position. 4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID is known for its potential applications in various industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID is used as a reactant for the preparation of N-terminal anthranoyl-phenylalanine derivatives, which serve as CCK1 receptor antagonists. These antagonists are crucial in the development of drugs targeting various gastrointestinal disorders and other conditions related to the CCK1 receptor.
Used in Pharmaceutical Industry (continued):
4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID is also used as a reactant for the preparation of factor Xa inhibitors based on a 2-carboxyindole scaffold. These inhibitors play a significant role in the development of anticoagulant drugs, which are essential for the prevention and treatment of blood clot-related disorders.
Used in Pharmaceutical Industry (continued):
Furthermore, 4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID is utilized as a reactant for the synthesis of potent and selective non-imidazole human histamine H4 receptor antagonists. These antagonists are vital in the development of medications for treating various allergic and inflammatory conditions, as well as other diseases associated with the histamine H4 receptor.
Used in Antiviral Drug Development:
In addition to its applications in the pharmaceutical industry, 4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID is used in the preparation of novel oxalyl piperazines active against the hepatitis B virus (HBV). These compounds are being investigated for their potential as antiviral agents, offering new treatment options for patients suffering from HBV infections.
Check Digit Verification of cas no
The CAS Registry Mumber 18474-60-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,4,7 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 18474-60:
(7*1)+(6*8)+(5*4)+(4*7)+(3*4)+(2*6)+(1*0)=127
127 % 10 = 7
So 18474-60-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO2/c1-6-3-2-4-7-5-8(10(12)13)11-9(6)7/h2-5,11H,1H3,(H,12,13)
18474-60-7Relevant articles and documents
The first potent and selective non-imidazole human histamine H4 receptor antagonists
Jablonowski, Jill A.,Grice, Cheryl A.,Chai, Wenying,Dvorak, Curt A.,Venable, Jennifer D.,Kwok, Annette K.,Ly, Kiev S.,Wei, Jianmei,Baker, Sherry M.,Desai, Pragnya J.,Jiang, Wen,Wilson, Sandy J.,Thurmond, Robin L.,Karlsson, Lars,Edwards, James P.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 3957 - 3960 (2007/10/03)
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.
