184766-45-8 Usage
Description
3-(2-METHYL-1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE is an organic compound characterized by its colorless oil appearance. It is a derivative of pyridine with a methyl group at the 6th position and a 2-methyl-1,3-dioxolan-2-yl group at the 3rd position. 3-(2-METHYL-1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE is known for its role in the synthesis and biological activity of metabolites related to certain pharmaceutical agents.
Uses
Used in Pharmaceutical Industry:
3-(2-METHYL-1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE is used as an intermediate in the synthesis of metabolites for the antidiabetic and antihyperglycemic agent Pioglitazone (P471000). Its role in the synthesis process is crucial for the development of this medication, which is utilized in the treatment of type 2 diabetes.
Used in Chemical Research:
As a colorless oil, 3-(2-METHYL-1,3-DIOXOLAN-2-YL)-6-METHYLPYRIDINE can also be employed in various chemical research applications. Its unique structure and properties make it a valuable compound for studying the effects of different functional groups on the overall behavior and reactivity of the molecule. This can lead to the discovery of new compounds with potential applications in various fields, including pharmaceuticals, materials science, and environmental science.
Check Digit Verification of cas no
The CAS Registry Mumber 184766-45-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,7,6 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 184766-45:
(8*1)+(7*8)+(6*4)+(5*7)+(4*6)+(3*6)+(2*4)+(1*5)=178
178 % 10 = 8
So 184766-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO2/c1-8-3-4-9(7-11-8)10(2)12-5-6-13-10/h3-4,7H,5-6H2,1-2H3
184766-45-8Relevant articles and documents
Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone
Tanis, Steven P.,Parker, Timothy T.,Colca, Jerry R.,Fisher, Roberta M.,Kletzein, Rolf F.
, p. 5053 - 5063 (1996)
Pioglitazone (5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4- thiazolidinedione, 2) is a prototypical antidiabetic thiazolidinedione that had been evaluated for possible clinical development. Metabolites 6-9 have been identified after dosing of rats and dogs. Ketone 10 has not yet been identified as a metabolite but has been added to the list as a putative metabolite by analogy to alcohol 6 and ketone 7. We have developed improved syntheses of pioglitazone (2) metabolites 6-9 and the putative metabolite ketone 10. These entities have been compared in the KKA(y) mouse model of human type-II diabetes to pioglitazone (2). Ketone 10 has proven to be the most potent of these thiazolidinediones in this in vivo assay. When 6-10 were compared in vitro in the 3T3-L1 cell line to 2, for their ability to augment insulin-stimulated lipogenesis, 10 was again the most potent compound with 6, 7, and 9 roughly equivalent to 2. These data suggest that metabolites 6, 7, and 9 are likely to contribute to the pharmacological activity of pioglitazone (2), as had been previously reported for ciglitazone (1).
