184970-01-2Relevant articles and documents
Cyclic urea derivatives as potent NK1 selective antagonists
Shue, Ho-Jane,Chen, Xiao,Shih, Neng-Yang,Blythin, David J.,Paliwal, Sunil,Lin, Ling,Gu, Danlin,Schwerdt, John H.,Shah, Sapna,Reichard, Gregory A.,Piwinski, John J.,Duffy, Ruth A.,Lachowicz, Jean E.,Coffin, Vicki L.,Liu, Fei,Nomeir, Amin A.,Morgan, Cynthia A.,Varty, Geoffrey B.
, p. 3896 - 3899 (2005)
A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compoun
