185200-33-3

Basic information

• Product Name: Benzeneacetic acid, 3-bromo-4-nitro-, methyl ester
• CAS NO: 185200-33-3
• Molecular Formula: C9H8BrNO4
• Molecular Weight: 274.071
• Mol File: 185200-33-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 3-bromo-4-nitro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 3-bromo-4-nitro-, methyl ester(185200-33-3)
• EPA Substance Registry System: Benzeneacetic acid, 3-bromo-4-nitro-, methyl ester(185200-33-3)

Safety Data

• Hazardous Substances Data: 185200-33-3(Hazardous Substances Data)

Usage

General Description

Benzeneacetic acid, 3-bromo-4-nitro-, methyl ester is a chemical compound with the molecular formula C9H8BrNO4. It is known for its powerful antibacterial and antifungal properties, and is widely used in the production of pharmaceuticals and agricultural chemicals. Benzeneacetic acid, 3-bromo-4-nitro-, methyl ester is also used in the manufacturing of dyes, perfumes, and other organic compounds. However,

Upstream product

• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 53088-68-9 methyl 3-chlorophenylacetate 
• 594844-44-7 2-(3-bromo-4-nitrophenyl)malonic acid tert-butyl ester methyl ester 
• 124840-60-4 3-Brom-4-nitro-benzylcyanid 
• 67-56-1 methanol 
• 90004-95-8 3-Brom-4-nitro-phenylessigsaeure 
• 31938-07-5 (3-bromophenyl)acetonitrile 
• 1878-67-7 3-Bromophenylacetic acid 

Downstream Products

• 209809-20-1 4-amino-3-bromophenylacetic acid methyl ester 
• 924309-89-7 methyl (4-nitro-3-trimethylsilylethynylphenyl)acetate 
• 594844-45-8 (3-dimethylamino-4-nitrophenyl)acetic acid methyl ester 
• 317356-81-3 methyl 3-bromo-4-[N'-(2-bromophenyl)ureido] phenylacetate 
• 317356-78-8 methyl 3-bromo-4-[N'-(2-chlorophenyl)ureido] phenylacetate 
• 317356-75-5 methyl 3-bromo-4-[N'-(2-methylphenyl)ureido] phenylacetate 
• 317356-82-4 (3-bromo-4-[N'-(2-bromophenyl)ureido]phenyl)acetic acid 
• 317356-79-9 (3-bromo-4-[N'-(2-chlorophenyl)ureido]phenyl)acetic acid 
• 317356-76-6 (3-bromo-4-[N'-(2-methylphenyl)ureido]phenyl)acetic acid 
• 924309-81-9 (3-ethyl-4-[N'-(2-methylphenyl)ureido]phenyl)acetic acid 
• 924309-77-3 methyl (4-amino-3-ethylphenyl)acetate 
• 924309-90-0 methyl (3-ethynyl-4-nitrophenyl)acetate 
• 317356-83-5 C₂₈H₂₆Br₂FN₃O₅ 
• 317356-80-2 C₂₈H₂₆BrClFN₃O₅ 

Relevant articles and documents

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists

A series of benzoic acid derivatives was synthesized as VLA-4 antagonists. Introduction of chlorine or bromine into the 3-position on the central benzene of the diphenylurea portion as in lead compound 2 led to improvement in the pharmacokinetic properties. In particular, 12l demonstrated an acceptable plasma clearance and bioavailability in mice and rats as well as dogs (mice, CL = 18.5 ml/min/kg, F = 28 %; rats, CL = 5.2 ml/min/kg, F = 36 %; dogs, CL = 3.6 ml/min/kg, F = 55 %). Additionally, 12l exhibited potent activity with an IC50 value of 0.51 nM and efficacy by oral administration at a dosage of 10 mg/kg in a rat pleurisy model.

ESTER COMPOUND AND MEDICINAL USE THEREOF

A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1") (wherein ???R1 and R2 are each hydrogen atom or optionally substituted aryl, etc.; ???X is -COO- or -CON(R10)-; ???R3 and R4 are each hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy, etc.; ???R5, R6 and R7 are each hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy, etc.; ???R8 and R9 are each independently hydrogen atom, C1-C6 alkyl, -CON(R18)(R19) or -COO(R20), etc.; ???ring A, ring B and ring C are each independently aryl or heterocycle residue, etc.; ???Alk1 and Alk2 are each independently alkanediyl, etc.; ???l and m are each an integer of 0 or 1 to 3) or a prodrug thereof, or a pharmaceutically acceptable salt of either. The therapeutic agent selectively inhibits MTP in the small intestine, thus causes no such side effect as a fatty liver.

Synthesis of Tiliacora alkaloids. III: Synthesis of biaryls by the Ullmann reaction

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