185213-03-0

Basic information

• Product Name: Butabindide oxalate
• Synonyms: [S-(R*,R*)]-1-(2-Amino-1-oxobutyl)-N-butyl-2,3-dihydro-1H-indole-2-carboxamide ethanedioate
• CAS NO: 185213-03-0
• Molecular Formula: C19H27N3O6
• Molecular Weight: 393.43418
• EINECS: -0
• Product Categories: Inhibitor of tripeptidyl peptidase II (TPPII).
• Mol File: 185213-03-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 142 °C
• Appearance: /
• CAS DataBase Reference: Butabindide oxalate(CAS DataBase Reference)
• NIST Chemistry Reference: Butabindide oxalate(185213-03-0)
• EPA Substance Registry System: Butabindide oxalate(185213-03-0)

Safety Data

• Hazardous Substances Data: 185213-03-0(Hazardous Substances Data)

Usage

Description

Butabindide oxalate is a potent and selective inhibitor of cholecystokinin-inactivating peptidase/tripeptidyl peptidase 2 (CCK-inactivating peptidase/TPP-2) with a Ki value of 7 nM. It demonstrates high selectivity for this enzyme over a range of serine proteases and CCK receptors. Butabindide oxalate has been shown to increase levels of CCK octapeptide in depolarized rat cerebral cortex slices and inhibit the peptidase in mouse liver and brain. Additionally, it enhances the delay in gastric emptying induced by CCK octapeptide and reduces food intake in mice.

Uses

Used in Pharmaceutical Industry:
Butabindide oxalate is used as a therapeutic agent for the treatment of gastrointestinal disorders. Its ability to inhibit CCK-inactivating peptidase/TPP-2 leads to increased levels of CCK octapeptide, which can help in modulating gastric emptying and reducing food intake, making it a potential treatment option for conditions such as obesity and related gastrointestinal issues.
Used in Research Applications:
Butabindide oxalate is used as a research tool for studying the role of CCK-inactivating peptidase/TPP-2 in various biological processes. Its high selectivity for the enzyme makes it a valuable compound for investigating the functions of this peptidase and its involvement in different physiological and pathological conditions.
Used in Drug Development:
Butabindide oxalate serves as a lead compound in the development of new drugs targeting CCK-inactivating peptidase/TPP-2. Its potent inhibition of the enzyme and the observed effects on gastric emptying and food intake can be further explored and optimized to develop more effective treatments for gastrointestinal disorders and potentially other conditions related to the regulation of CCK signaling.