18531-44-7Relevant articles and documents
An Efficient One-Pot Enzymatic Synthesis of Cardiac Glycosides with Varied Sugar Chain Lengths
Huang, Wei,Wen, Chao,Zhou, Zhen-Ru,Fu, Zhi-Hao,Katz, Adriana,Plotnikov, Alexander,Karlish, Steven J. D.,Jiang, Ren-Wang
supporting information, p. 3114 - 3119 (2019/05/22)
An efficient one-pot enzymatic synthesis of cardiac glycosides with varied sugar chain lengths (average yield >80%) was carried out through sequential glycosylation using a steroid glycosyltransferase UGT74AN3 from Catharanthus roseus and a cyclodextrin glycosyltransferase from Bacillus licheniformis. A series of cardiac glycosides were obtained and showed enhanced affinity and selectivity for inhibition of the α2 isoform of Na+/K+-ATPase. These findings demonstrate the significant potential of the one-pot biocatalytic approach in the synthesis of diverse cardiac glycosides as potentially safer cardiotonic agents. (Figure presented.).
Biotransformation of digitoxigenin by cultured ginseng cells
Kawaguchi, Kiichiro,Watanabe, Takashi,Hirotani, Masao,Furuya, Tsutomu
, p. 667 - 669 (2007/10/03)
Nine compounds, including a new compound (digitoxigenin β-D-glucoside malonyl ester), were isolated as biotransformation products of digitoxigenin by cell suspension cultures of Panax ginseng (Pg-3 cell line). At the same time, two known products were identified by TLC and HPLC.
