185383-62-4

Basic information

• Product Name: 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole
• Synonyms: 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole
• CAS NO: 185383-62-4
• Molecular Formula: C16H16FNO2
• Molecular Weight: 273
• Mol File: 185383-62-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole(185383-62-4)
• EPA Substance Registry System: 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole(185383-62-4)

Safety Data

• Hazardous Substances Data: 185383-62-4(Hazardous Substances Data)

Upstream product

• 399-52-0 5-fluoro-1H-indole 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 185383-64-6 4-(5-Fluoro-1H-3-indolyl)-cyclohexanone 
• 1026435-68-6 [4-(5-Fluoro-1H-indol-3-yl)-cyclohexyl]-acetic acid ethyl ester 
• 185383-68-0 [4-(5-fluoro-1H-indol-3-yl)cyclohexylidene]acetic acid ethyl ester 

Relevant articles and documents

Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives

Based on the previously reported discovery lead, 3-(cis-4-(4-(1H-indol-4-yl)piperazin-1-yl)cyclohexyl)-5-fluoro-1H-indole (2), a series of related arylpiperazin-4-yl-cyclohexyl indole analogs were synthesized then evaluated as 5-HT transporter inhibitors

N-ARYL-(HOMOPIPERAZINYL)-CYCLOHEXYL AMINES

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[(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders

This invention provides novel compounds and pharmaceutical compositions and methods of using the compounds in the treatment of central nervous system disorders, such as anxiety and depression, the compounds having the formula I: wherein: X is N—R, O, S(O)m; m is 0 to 2; n is 0 to 4; Ar is an aryl group of 6 to 12 carbon atoms optionally substituted with 1 to 3 R3groups, or a heteroaryl group of 4 to 10 carbon atoms optionally substituted with 1 to 3 R3groups; R and R2are independently H, straight chain alkyl of 1 to 6 carbon atoms, branched alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms, aminocarbonyl, or alkylaminocarbonyl of 1 to 4 carbon atoms; R1and R3are independently H, straight chain alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, halo, alkoxy group of 1 to 4 carbon atoms, haloalkyl of 1 to 4 carbon atoms, OH, nitro, amino, sulfonyl, CN, carboxy, alkoxycarbonyl of 1 to 4 carbon atoms, alkylcarbonyl of 1 to 4 carbon atoms, aminocarbonyl, or alkylaminocarbonyl of 1 to 4 carbon atoms; or a pharmaceutically acceptable salt thereof.