185461-58-9

Basic information

• Product Name: L-Leucine, N-[(4S)-2,5-dimethyl-1,3-dioxo-4-(phenylmethoxy)hexyl]-, 2,2,2-trichloroethyl ester
• CAS NO: 185461-58-9
• Molecular Formula: C23H32Cl3NO5
• Molecular Weight: 508.87
• Mol File: 185461-58-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[(4S)-2,5-dimethyl-1,3-dioxo-4-(phenylmethoxy)hexyl]-, 2,2,2-trichloroethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(4S)-2,5-dimethyl-1,3-dioxo-4-(phenylmethoxy)hexyl]-, 2,2,2-trichloroethyl ester(185461-58-9)
• EPA Substance Registry System: L-Leucine, N-[(4S)-2,5-dimethyl-1,3-dioxo-4-(phenylmethoxy)hexyl]-, 2,2,2-trichloroethyl ester(185461-58-9)

Safety Data

• Hazardous Substances Data: 185461-58-9(Hazardous Substances Data)

Upstream product

• 162307-38-2 N^α-(tert-butoxycarbonyl)-L-leucine 2',2',2'-trichloroethyl ester 
• 69472-81-7 H-S-Leu-OTce 
• 110840-39-6 (S)-(+)-2-(benzyloxy)-3-methylbutanal 
• 110298-78-7 methyl (S)-2-(benzyloxy)-3-methylbutanoate 
• 129919-92-2 (S)-2-(benzyloxy)-3-methylbutane-1-ol 
• 24347-63-5 methyl (S)-2-hydroxy-3-methylbutanoate 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 72-18-4 L-valine 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 

Downstream Products

• 185461-55-6 Boc-(R)-N(Me)-Leu-Thr[H-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OH 
• 185461-60-3 (S)-1-[(S)-2-((S)-4-Benzyloxy-2,5-dimethyl-3-oxo-hexanoylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 185461-53-4 Boc-(R)-N(Me)-Leu-Thr[Z-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OTce 
• 185461-54-5 Boc-(R)-N(Me)-Leu-Thr[Z-N(Me)-O(Me)-Tyr]-Ist(TBDMS)-Hip-Leu-Pro-OH 
• 137219-37-5 dehydrodidemnin B 
• 185461-50-1 cyclo-[N(Me)-O(Me)-Tyr-O-[Boc-(R)-N(Me)-Leu->-Thr-Ist(TBDMS)-Hip-Leu-Pro-> 
• 185461-59-0 (S)-2-((S)-4-Benzyloxy-2,5-dimethyl-3-oxo-hexanoylamino)-4-methyl-pentanoic acid 

Relevant articles and documents

Synthesis of derivatives of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnins

The syntheses of the two protected derivatives 7 and 16 of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnin family of antineoplastic macrocyclic depsipeptides are described. The preparation of 7 was carried out by modificat