18549-16-1Relevant articles and documents
Synthesis of 9-arylidene derivatives of deoxyvasicinone
Shakhidoyatov,Kaisarov
, p. 59 - 61 (1998)
A simple method has been developed for obtaining 9-arylidenedeoxyvasicinones by condensing deoxyvasicinone with aromatic aldehydes in the presence of glacial acetic acid. The yields of reaction products amount to 69-95%.
A convenient divergent approach to the alkaloids isaindigotone and luotonin A
Molina,Tarraga,Gonzalez-Tejero
, p. 1523 - 1525 (2000)
Deoxyvasicinone has been used as the key intermediate to prepare the alkaloids isaindigotone and luotonin A. This intermediate is directly converted into isaindigotone by condensation with 4-acetoxy-3,5-dimethoxybenzaldehyde; alternatively oxidation with SeO2 afforded the pyrrolo[2,1-b]quinazoline-3,9-dione, a putative precursor of the luotonin A.
Structure activity relationship of arylidene pyrrolo and pyrido [2,1-b] quinazolones as cytotoxic agents: Synthesis, SAR studies, biological evaluation and docking studies
Mangla, Veenu,Nepali, Kunal,Singh, Gagandip,Singh, Jagjeet,Guru, Santosh,Gupta, Manish Kumar,Mahajan, Priya,Saxena, Ajit Kumar,Dhar, Kanaya Lal
, p. 642 - 650 (2013/09/23)
Tubulin is the one of the most useful and strategic molecular targets for anticancer drugs. Agents that bind in Colchicine-binding site of tubulin include Phenstatin, Combretastatin A-4, Colchicine, Steganacin, Podophyllotoxin and certain other synthetic analogues of these compounds. Arylidene pyrollo and pyrido [2,1-b] quinazolones (isoindigatone and its synthetic analogues) have been earlier reported to be tubulin inhibitors evidenced by tubulin polymerization assay. The present study is an extension of the library of the isoindigatone and its synthetic analogues to generate the structure activity relationship. The study explores the role of the arylidene ring and also provides some intresting observations such as the placement of bicyclic ring such as naphylidene for potential activity. Some of the important interactions of KNH-3 and KNH-11 with the amino acid residues of active site of Tubulin have also been observed by molecular modeling.
A facile synthesis of α,α′-bis(substituted-benzylidene)-cycloalkanones and substituted-benzylidene heteroaromatics: utility of NaOAc as a catalyst for aldol-type reaction
Motiur Rahman,Jeong, Byeong-Seon,Kim, Dong Hyeon,Park, Jung Ki,Lee, Eung Seok,Jahng, Yurngdong
, p. 2426 - 2431 (2007/10/03)
Utility of NaOAc in glacial HOAc as a catalyst for aldol-type condensation reactions was examined. Reactions of cycloalkanones and selected heteroaromatics with various aldehydes in the presence of NaOAc in glacial HOAc provided α,α′-bis(substituted-benzylidene)cycloalkanones and substituted-benzylidene heteroaromatics, respectively, in good yields.
