185507-82-8

Basic information

• Product Name: 4-Piperidinone, 1-[4-(4-fluorophenyl)-4-oxobutyl]-, 4-[[2-nitro-4-(trifluoromethyl)phenyl]hydrazone]
• CAS NO: 185507-82-8
• Molecular Formula: C22H22F4N4O3
• Molecular Weight: 466.435
• Mol File: 185507-82-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Piperidinone, 1-[4-(4-fluorophenyl)-4-oxobutyl]-, 4-[[2-nitro-4-(trifluoromethyl)phenyl]hydrazone](CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinone, 1-[4-(4-fluorophenyl)-4-oxobutyl]-, 4-[[2-nitro-4-(trifluoromethyl)phenyl]hydrazone](185507-82-8)
• EPA Substance Registry System: 4-Piperidinone, 1-[4-(4-fluorophenyl)-4-oxobutyl]-, 4-[[2-nitro-4-(trifluoromethyl)phenyl]hydrazone](185507-82-8)

Safety Data

• Hazardous Substances Data: 185507-82-8(Hazardous Substances Data)

Upstream product

• 51787-84-9 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 39146-45-7 N-<3-(4-Fluorobenzoyl)propyl>-4-piperidone 
• 1513-50-4 2-nitro-4-(trifluoromethyl)phenylhydrazine 

Relevant articles and documents

Preparation and pharmacological activities of spiro[3,4-dihydro-6/7-R-1,2,4-benzotriazine-3,4'-(1'-substituted)piper idines]

A set of spiro[3,4-dihydro-1,2,4-benzotriazines-3,4'-piperidine] derivatives was prepared and subjected to a broad pharmacological screening. Many of these compounds are characterized by a 3-(4-fluorobenzoyl)propyl substituent on the piperidine nitrogen, thus resembling the p-fluorobutyrophenone antipsychotics. Modest dopamine antagonism was observed for the tested compounds, which however were mainly endowed with analgesic and antihypertensive activities. Antihypercholesterolemic activity was also seen in compound 5, which represents an interesting new lead, being completely structurally unrelated to the known agents in this field.