185515-75-7Relevant articles and documents
Synthesis of derivatives of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnins
Gonzalez, Isabel,Jou, Gemma,Caba, Josep Maria,Albericio, Fernando,Lloyd-Williams, Paul,Giralt, Ernest
, p. 1427 - 1433 (2007/10/03)
The syntheses of the two protected derivatives 7 and 16 of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnin family of antineoplastic macrocyclic depsipeptides are described. The preparation of 7 was carried out by modificat