185516-60-3Relevant articles and documents
From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2-inhibitors
Black,Bayly,Belley,Chan,Charleson,Denis,Gauthier,Gordon,Guay,Kargman,Lau,Leblanc,Mancini,Ouellet,Percival,Roy,Skorey,Tagari,Vickers,et al.
, p. 725 - 730 (1996)
A series of potent and highly selective cyclooxygenase-2 inhibitors have been prepared by replacing the benzoyl group of indomethacin with a 4-bromobenzyl group, and by extending the acetic acid side chain. These compounds show anti-inflammatory activity in rats with no evidence of GI toxicity, even at high doses.
