185557-63-5

Basic information

• Product Name: 1,2,4-Oxadiazol-5(2H)-one, 3-(4-fluorophenyl)-
• CAS NO: 185557-63-5
• Molecular Formula: C8H5FN2O2
• Molecular Weight: 180.138
• Mol File: 185557-63-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazol-5(2H)-one, 3-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazol-5(2H)-one, 3-(4-fluorophenyl)-(185557-63-5)
• EPA Substance Registry System: 1,2,4-Oxadiazol-5(2H)-one, 3-(4-fluorophenyl)-(185557-63-5)

Safety Data

• Hazardous Substances Data: 185557-63-5(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.
2. Heterocyclic compound

Explanation

A heterocyclic compound is a cyclic compound that contains atoms of at least two different elements, in this case, oxygen and nitrogen.
3. Five-membered ring

Explanation

The compound has a ring structure consisting of five atoms.
4. Contains oxygen and nitrogen atoms

Explanation

The five-membered ring of the compound includes both oxygen and nitrogen atoms, which contribute to its unique properties.
5. Potential applications in the pharmaceutical industry

Explanation

Due to its various biological activities, the compound has the potential to be used in the development of pharmaceutical drugs.
6. Exhibits antibacterial, antifungal, and antitumor properties

Explanation

The compound has been found to possess these biological activities, making it a candidate for further research and development in the medical field.
7. Used as a building block in the synthesis of pharmaceutical drugs and agrochemicals

Explanation

The compound can be used as a starting material or intermediate in the synthesis of various drugs and chemicals used in agriculture.
8. Studied for potential role in the treatment of neurological disorders

Explanation

Research is being conducted to explore the compound's potential therapeutic effects on neurological conditions.
9. Acts as a ligand in the development of new metal-based drugs

Explanation

The compound can bind to metal ions, which may be useful in the development of new drugs that incorporate metal ions for various therapeutic purposes.

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 22179-78-8 4-fluoro-benzamidoxime 
• 616-38-6 carbonic acid dimethyl ester 
• 541-41-3 chloroformic acid ethyl ester 
• 405-99-2 para-fluorostyrene 
• 1194-02-1 4-fluorobenzonitrile 
• 530-62-1 1,1'-carbonyldiimidazole 
• 22179-78-8 (Z)-4-fluoro-N'-hydroxybenzimidamide 

Downstream Products

• 1024614-31-0 4-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]morpholine 
• 1262319-87-8 3-(4-fluorophenyl)benzo[e][1,2,4]triazine 

Relevant articles and documents

Copper-Catalyzed Selective N-Arylation of Oxadiazolones by Diaryliodonium Salts

Here, we report the method for copper-catalyzed N-arylation of diverse oxadiazolones by diaryliodonium salts under mild conditions in high yields (up to 92%) using available CuI as a catalyst. The developed method allows utilizing both symmetric and unsymmetric diaryliodonium salts bearing auxiliary groups such as 2,4,6-trimethoxyphenyl (TMP). We found that the steric effects in aryl moieties determined the chemoselectivity of N- and O-arylation of the 1,2,4-oxadiazol-5(4H)-ones. Mesityl-substituted diaryliodonium salts demonstrated the high potential as a selective arylation reagent. The structural study suggests that steric accessibility of N-atom in 1,2,4-oxadiazol-5(4H)-ones impact to arylation with sterically hindered diaryliodonium salts. The synthetic application of proposed method was also demonstrated on selective arylation of 1,3,4-oxadiazol-2(3H)-ones and 1,2,4-oxadiazole-5-thiol. (Figure presented.).

SUBSTITUENT-INCLUDING UREA COMPOUND

An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases. The present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. (Each symbol in Formula (1) has the same definition as that described in the specification.)

Green synthesis method of oxadiazole derivatives

The invention relates to the field of organic chemistry, overcomes disadvantages in the synthesis of oxadiazole derivatives in the prior art, and provides a green synthesis method of the oxadiazole derivatives. The method comprises the following specific steps: (1) adding a basic reagent, dropwise adding a carbonylation reagent, stirring evenly, and back-flowing at 100 DEG C, wherein water is usedas a solvent, N-hydroxybenzamidine or substituted N-hydroxybenzamidine is used as a raw material, the reaction time is 1-5 hours; and (2) after the reaction is finished, cooling, standing, adjustingpH to 3-4 with 1 mol/L diluted HCl acidification reaction solution, performing suction filtration, collecting filter cakes, washing the filter cakes with water, and performing vacuum drying to finallyobtain the oxadiazole derivative. N-hydroxybenzamidine or substituted N-hydroxybenzamidine and a carbonylation reagent are used as the raw materials, under the action of the basic reagent, the oxadiazole derivatives can be synthesized in one step in water, and the two steps of esterification and cyclization are simplified to one step, thus greatly shortening the reaction time and increasing the reaction yield. The method has the advantages of being mild in reaction conditions, convenient to separate and purify, green and environmentally friendly.