185622-83-7

Basic information

• Product Name: 5-Benzyloxy-3-(2-ethoxycarbonyl-2-fluoro-1-hydroxy-ethyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester
• Synonyms: 5-Benzyloxy-3-(2-ethoxycarbonyl-2-fluoro-1-hydroxy-ethyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester
• CAS NO: 185622-83-7
• Molecular Weight: 458.487
• Mol File: 185622-83-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Benzyloxy-3-(2-ethoxycarbonyl-2-fluoro-1-hydroxy-ethyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzyloxy-3-(2-ethoxycarbonyl-2-fluoro-1-hydroxy-ethyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester(185622-83-7)
• EPA Substance Registry System: 5-Benzyloxy-3-(2-ethoxycarbonyl-2-fluoro-1-hydroxy-ethyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester(185622-83-7)

Safety Data

• Hazardous Substances Data: 185622-83-7(Hazardous Substances Data)

Upstream product

• 56795-92-7 1H-Pyrrolo<2,3-c>pyridine-3-carbaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 459-72-3 ethyl 2-fluoroacetate 
• 185622-81-5 5-Benzyloxy-3-formyl-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 185622-85-9 3-(5-Benzyloxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-fluoro-propionic acid methyl ester 
• 140870-34-4 (Z)-5-Benzyloxy-3-(2-fluoro-2-ethoxycarbonylethenyl)-1H-pyrrolo<2,3-c>pyridine 
• 185622-84-8 3-(1-Acetoxy-2-ethoxycarbonyl-2-fluoro-ethyl)-5-benzyloxy-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis of analogues of porphobilinogen

Syntheses are described of several analogues of porphobilinogen intended as substrates and/or inhibitors of porphobilinogen deaminase (hydroxymethylbilane synthase). 2-Methylporphobilinogen 12 has been synthesised from α-methylpyrrole 6, whereas a phosphonate analogue 20 of porphobilinogen, 8,9-didehydroporphobilinogen 26 and 9-fluoroporphobilinogen 38 have all been made from the 1H-pyrrolo[2,3-c]pyridine 14. The best route to 38 avoids fluoroacrylate 28 because of loss of fluorine during reduction of the double bond.