185671-63-0Relevant articles and documents
3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: Synthesis, antimicrobial and antiviral activity. II
Invidiata,Simoni,Scintu,Pinna
, p. 659 - 664 (2007/10/03)
A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b] [1,3,4]thiadiazole derivatives was prepared and tested to evaluate their antimycotic and antibacterial activities. Anti-HIV-1 activity has also been investigated. Among the test compounds, derivatives 10a-14a and 16c showed anti-HIV-1 activity at concentrations slightly below those cytotoxic. Substitutions at 3 and 6 positions seems to be important in lowering the cytotoxicity of compounds.