185910-12-7

Basic information

• Product Name: 1H-Imidazole-2-carboxaldehyde,1,4,5-trimethyl-(9CI)
• Synonyms: 1H-Imidazole-2-carboxaldehyde,1,4,5-trimethyl-(9CI);1,4,5-Trimethylimidazole-2-carboxaldehyde;1,4,5-trimethyl-1H-imidazole-2-carbaldehyde(SALTDATA: FREE);1,4,5-trimethyl-2-imidazolecarboxaldehyde;1,4,5-trimethylimidazole-2-carbaldehyde
• CAS NO: 185910-12-7
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.169
• Product Categories: AMINETERTIARY
• Mol File: 185910-12-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 289℃
• Flash Point: 128℃
• Appearance: /
• Density: 1.09
• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Imidazole-2-carboxaldehyde,1,4,5-trimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-2-carboxaldehyde,1,4,5-trimethyl-(9CI)(185910-12-7)
• EPA Substance Registry System: 1H-Imidazole-2-carboxaldehyde,1,4,5-trimethyl-(9CI)(185910-12-7)

Safety Data

• Hazardous Substances Data: 185910-12-7(Hazardous Substances Data)

Usage

General Description

1H-Imidazole-2-carboxaldehyde, 1,4,5-trimethyl-(9CI) is a chemical compound that belongs to the class of imidazoles, specifically the class of substituted imidazoles. As an imidazole derivative, this compound includes a five-membered aromatic ring made up of two nitrogen atoms and three carbon atoms, with additional functional groups. 1H-Imidazole-2-carboxaldehyde,1,4,5-trimethyl-(9CI) is generally known for its potential use in chemical synthesis, as its structure and properties could be valuable in the creation of more complex molecules or as part of chemical reactions. However, details about its specific uses, safety, or potential hazards are not readily available. Therefore, it is crucial to handle this substance with care, following any applicable guidelines for chemical safety.

InChI:InChI=1/C7H10N2O/c1-5-6(2)9(3)7(4-10)8-5/h4H,1-3H3

Upstream product

• 20185-22-2 1,4,5-Trimethylimidazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 185910-13-8 (1,4,5-Trimethyl-1H-imidazol-2-yl)-methanol 
• 1207454-70-3 ethyl 2-(4-fluorophenyl)-4-oxo-3-(1,4,5-trimethyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate 

Relevant articles and documents

Asymmetric Copper(II)-catalysed nitroaldol (Henry) reactions utilizing a chiral C1-symmetric dinitrogen ligand

A series of stable chiral C1-symmetric dinitrogen ligands were conveniently synthesized in high yields by condensation of chiral amines [(-)-exo-bornylamine or (+)-(1S,2S,5R)-menthylamine] with various substituted imidazolecarbaldehydes. With the assistance of base, the ligand L1 in combination with CuCl2·2H2O (2.5 mol-% or 5.0 mol-%) can efficiently promote nitroaldol (Henry) reactions between a variety of aldehydes and nitromethane. Both aromatic and aliphatic aldehydes were tolerated in our catalytic system, affording the expected nitroalcohol products in high yields (up to 97%) and with good enantioselectivities (up to 96%) under mild reaction conditions. A series of chiral C1-symmetric dinitrogen ligands were conveniently synthesized in high yields by condensations of chiralamines with various substituted imidazolecarbaldehydes. The ligand L1 in conjunction with CuCl2·2H2O can efficiently promote nitroaldol (Henry) reactions between various aldehydes and nitromethane in high yields (up to 97%) and with good enantioselectivities (up to 96%).

DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.