18593-47-0

Basic information

• Product Name: 2-benzyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one
• Synonyms: 2-benzyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one
• CAS NO: 18593-47-0
• Molecular Formula: C₁₅H₁₄N₂OS
• Molecular Weight: 270.34946
• Mol File: 18593-47-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-benzyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one(18593-47-0)
• EPA Substance Registry System: 2-benzyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one(18593-47-0)

Safety Data

• Hazardous Substances Data: 18593-47-0(Hazardous Substances Data)

Upstream product

• 4971-77-1 ethyl 2-phenylethanimidoate 
• 4815-24-1 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester 
• 140-29-4 phenylacetonitrile 
• 645-54-5 2-phenylthioacetamide 
• 103-81-1 Benzeneacetamide 
• 122-51-0 orthoformic acid triethyl ester 
• 100-46-9 benzylamine 

Downstream Products

• 83548-59-8 2-Benzyl-4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine 
• 401511-14-6 2-benzyl-4-[(2-hydroxy)ethyl]amino-5,6-dimethylthieno[2,3-d]pyrimidine 
• 83548-74-7 5-Benzyl-8,9-dimethyl-tetrazolo[1,5-c]thieno[3,2-e]pyrimidine 
• 83548-66-7 (2-Benzyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-yl)-hydrazine 
• 1089813-89-7 2-benzyl-5,6-dimethyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidine 
• 1611471-57-8 4-(4-benzhydrylpiperazin-1-yl)-2-benzyl-5,6-dimethyl-4-thieno[2,3-d]pyrimidine 

Relevant articles and documents

Antiproliferative activity of novel thiophene and thienopyrimidine derivatives

A novel series of newly synthesized thiophene derivatives, ethyl-4,5-dimethyl-2-(3-(3,4,5-trimethoxyphenyl)thioureido)thiophene-3- carboxylate 3, ethyl-2-[(2-(dimethylamino)ethoxy)mercapto)methyleneamino)]-4,5- dimethyl-thiophene-3-carboxylate 9, thienopyrimidines 4, 7, 10-20, triazolothienopyrimidines 5, 6 were prepared and tested for their antiproliferative activity. The structures of the synthesized compounds were confirmed on the basis of elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectral data. The results showed that the synthesized compounds were more active on breast cancer than on colon cancer cell lines and the most potent compounds in this study are compounds 3 and 13 which exerted remarkable activity against MDA-MB-231 (breast cancer) and HT-29 (colon cancer) cell lines with IC50 values (40.68, 49.22 μM) for compound 3 and (34.04, 45.62 μM) for compound 13. Also, compounds 4-6, 9 showed a moderate activity against breast cancer cell line, while compounds 15, 19 and 20 showed no activity. Georg Thieme Verlag KG Stuttgart New York.

Microwave-Assisted Synthesis of Novel 5-Substituted-2,3-dihydroimidazo[1,2-c]thieno[3,2-e]pyrimidines

A novel, facile microwave-assisted route for the synthesis of imidazo[1,2-c]thieno[3,2-e]pyrimidines 4 in quantitative yields is reported. The intermediates 4-chlorothieno[2,3-d]pyrimidines 3 were synthesized under one-pot reaction conditions.