186261-39-2

Basic information

• Product Name: (R)-2-[(E)-3-(2,4-Dimethoxy-phenyl)-acryloylamino]-3-methyl-butyric acid ethyl ester
• CAS NO: 186261-39-2
• Molecular Weight: 335.4
• Mol File: 186261-39-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-[(E)-3-(2,4-Dimethoxy-phenyl)-acryloylamino]-3-methyl-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-[(E)-3-(2,4-Dimethoxy-phenyl)-acryloylamino]-3-methyl-butyric acid ethyl ester(186261-39-2)
• EPA Substance Registry System: (R)-2-[(E)-3-(2,4-Dimethoxy-phenyl)-acryloylamino]-3-methyl-butyric acid ethyl ester(186261-39-2)

Safety Data

• Hazardous Substances Data: 186261-39-2(Hazardous Substances Data)

Upstream product

• 16909-09-4 (E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid 
• 17498-50-9 (R)-valine hydrochloride 

Relevant articles and documents

Synthesis of C-Alkylcalix[4] arenes. 4. Design, Synthesis, and Computational Studies of Novel Chiral Amido[4]resorcinarenes

In extending our studies involving BF3·Et2O-catalyzed reaction of cinnamic acid analogues, we have shown that amido derivatives also can afford [4]resorcinarene octamethyl ethers. Subsequently, chiral monomeric amides, derived from the mixed anhydride of cinnamic acid and L- or D-valine, upon treatment with BFa·Et2O, yielded for the first time chiral amido [4]resorcinarenes in enantiomerically pure forms. Four stereoisomers were isolated, and three of them were attributed the flattened-cone, chair, and 1,2-alternate conformations. The major product was assigned a novel chairlike structure, namely flattened partial cone 1. The flattened-cone stereoisomer, which was indicated by molecular modeling studies to be the most stable, became the major product under more drastic experimental conditions. Chromatographic studies on chiral phases revealed that the above tetramers could be used for the enantiodiscrimination of racemic molecules.