186298-52-2

Basic information

• Product Name: 3-iodo-1-methyl-4-nitro-1H-pyrazole
• Synonyms: 3-iodo-1-methyl-4-nitro-1H-pyrazole
• CAS NO: 186298-52-2
• Molecular Weight: 252.999
• Mol File: 186298-52-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-iodo-1-methyl-4-nitro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-iodo-1-methyl-4-nitro-1H-pyrazole(186298-52-2)
• EPA Substance Registry System: 3-iodo-1-methyl-4-nitro-1H-pyrazole(186298-52-2)

Safety Data

• Hazardous Substances Data: 186298-52-2(Hazardous Substances Data)

Upstream product

• 92525-10-5 3-iodine-1-methyl-1H-pyrazole 
• 20055-00-9 1-methyl-4-nitro-1H-pyrazol-3-ylamine 
• 3994-50-1 1-methyl-4-nitropyrazole 
• 34091-53-7 3,4-diiodo-1-methylpyrazole 

Downstream Products

• 66296-67-1 1-methyl-3,4-dinitropyrazole 

Relevant articles and documents

Direct iodination of 3- and 4-nitropyrazoles with a reagent based on iodine monochloride and silver sulfate

The reagent obtained from iodine monochloride and silver sulfate in sulfuric acid easily iodinates 1-methyl-3-nitropyrazole under mild conditions to give 4-iodo or 4,5-diiodo derivatives. 1-Methyl-4-nitropyrazole was also directly iodinated with this reagent for the first time.

Compound as well as preparation method and medical application thereof

The invention provides a compound as well as a preparation method and medical application thereof, the compound has a structure as shown in a general formula (I), and can also be a tautomer, a mesomer, a raceme, an enantiomer, a diastereoisomer, or a mixture form thereof, or a pharmaceutically acceptable salt thereof. According to the compound with the structure as shown in the general formula (I)provided by the invention, a specific main chain structure and a corresponding substituent group are selected, so that the obtained compound can be used as an arginase inhibitor, is relatively high in activity, and has a potential treatment prospect in various diseases.