186391-33-3Relevant articles and documents
Structural selectivity of aromatic diamidines
Chaires, Jonathan B.,Ren, Jinsong,Hamelberg, Donald,Kumar, Arvind,Pandya, Vandna,Boykin, David W.,Wilson, W. David
, p. 5729 - 5742 (2007/10/03)
Competition dialysis was used to study the interactions of 13 substituted aromatic diamidine compounds with 13 nucleic acid structures and sequences. The results show a striking selectivity of these compounds for the triplex structure poly dA:(poly dT)su
Small molecule inhibition of RNA/ligand binding
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, (2008/06/13)
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemp