186461-60-9

Basic information

• Product Name: 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene
• Synonyms: 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene
• CAS NO: 186461-60-9
• Molecular Weight: 431.491
• Mol File: 186461-60-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene(186461-60-9)
• EPA Substance Registry System: 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene(186461-60-9)

Safety Data

• Hazardous Substances Data: 186461-60-9(Hazardous Substances Data)

Upstream product

• 186462-14-6 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene 
• 1027833-34-6 (4-benzyloxy-2-dimethoxymethyl-5-methoxy-phenyl)-(2-chloro-pyridin-4-yl)-methanol 
• 155044-04-5 6-bromo-3-benzyloxy-4-methoxybenzaldehyde dimethyl acetal 
• 101066-61-9 2-chloropyridine-4-carbaldehyde 
• 186461-59-6 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene 

Downstream Products

• 222529-60-4 6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene 
• 186461-19-8 1-[2-{4-(3-pyridyl)-1(2H)-phthalazinon-2-yl}-4-pyridyl]-2,3-bis(hydroxymethyl)-6-benzyloxy-7-methoxynaphthalene hydrochloride 

Relevant articles and documents

Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: Synthesis and biological activities of a series of 1- pyridylnaphthalene derivatives

The structural requirements for potent and selective PDE4 inhibition were revealed in a 1-pyridylnaphthalene series, and the best compound (3kg, T-2585·HCl) was chosen for further biological evaluation (PDE4 inhibition IC50 = 0.13 nM, selectivi