186547-01-3

Basic information

• Product Name: BenzenecarboxiMidaMide, 3-[[(3S)-3-[[(7-Methoxy-2-naphthalenyl)sulfonyl]aMino]-2-oxo-1-pyrrolidinyl]Methyl]-
• Synonyms: BenzenecarboxiMidaMide, 3-[[(3S)-3-[[(7-Methoxy-2-naphthalenyl)sulfonyl]aMino]-2-oxo-1-pyrrolidinyl]Methyl]-;3-[[(3S)-3-[(7-methoxynaphthalen-2-yl)sulfonylamino]-2-oxopyrrolidin-1-yl]methyl]benzenecarboximidamide
• CAS NO: 186547-01-3
• Molecular Formula: C23H24N4O4S
• Molecular Weight: 452.52606
• Mol File: 186547-01-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzenecarboxiMidaMide, 3-[[(3S)-3-[[(7-Methoxy-2-naphthalenyl)sulfonyl]aMino]-2-oxo-1-pyrrolidinyl]Methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzenecarboxiMidaMide, 3-[[(3S)-3-[[(7-Methoxy-2-naphthalenyl)sulfonyl]aMino]-2-oxo-1-pyrrolidinyl]Methyl]-(186547-01-3)
• EPA Substance Registry System: BenzenecarboxiMidaMide, 3-[[(3S)-3-[[(7-Methoxy-2-naphthalenyl)sulfonyl]aMino]-2-oxo-1-pyrrolidinyl]Methyl]-(186547-01-3)

Safety Data

• Hazardous Substances Data: 186547-01-3(Hazardous Substances Data)

Upstream product

• 135-55-7 7-hydroxynaphthalene-2-sulfonic acid sodium salt 
• 186550-31-2 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide 
• 186550-17-4 [1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester 
• 56875-60-6 7-Methoxy-2-naphthalenesulfonyl chloride 
• 247030-74-6 7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(R)-yl]amide 

Relevant articles and documents

Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa

The discovery of a series of non-peptide factor Xa (FXa) inhibitors incorporating 3-(s)-amino-2-pyrrolidinone as a central template is described. After identifying compound 4, improvements in in vitro potency involved modifications of the liphophilic group and optimizing the angle of presentation of the amidine group to the S1 pocket of FXa. These studies ultimately led to compound RPR120844, a potent inhibitor of FXa (K1 = 7 nM) which shows selectivity for FXa over trypsin, thrombin, and several fibrinolytic serine proteinases. RPR120844 is an effective anticoagulant in both the rat model of FeCl2-induced carotid artery thrombosis and the rabbit model of jugular vein thrombus formation.