18655-48-6

Basic information

• Product Name: 3-(2-chlorophenyl)propan-1-amine
• Synonyms: 3-(2-chlorophenyl)propan-1-amine;3-(2-chlorophenyl)propan-1-amine(SALTDATA: FREE);2-Chloro-benzenepropanaMine
• CAS NO: 18655-48-6
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 169.65128
• Mol File: 18655-48-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 252.3°C at 760 mmHg
• Flash Point: 124.2°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 0.0195mmHg at 25°C
• Refractive Index: 1.545
• PKA: 10.12±0.10(Predicted)
• CAS DataBase Reference: 3-(2-chlorophenyl)propan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)propan-1-amine(18655-48-6)
• EPA Substance Registry System: 3-(2-chlorophenyl)propan-1-amine(18655-48-6)

Safety Data

• Hazardous Substances Data: 18655-48-6(Hazardous Substances Data)

Usage

General Description

3-(2-chlorophenyl)propan-1-amine, also known as 2-chloroamphetamine, is a chemical compound with the formula C9H12ClN. It is a substituted amphetamine that belongs to the phenylethylamine class and is structurally related to the neurotransmitter serotonin. 3-(2-chlorophenyl)propan-1-amine has been studied for its potential pharmacological effects, including its role as a psychoactive drug. It is considered to have psychostimulant and entactogenic properties, and has been investigated for its potential use as a medication for various mental health conditions. However, its use and distribution may be regulated due to its potential for abuse and dependence.

InChI:InChI=1/C9H12ClN/c10-9-6-2-1-4-8(9)5-3-7-11/h1-2,4,6H,3,5,7,11H2

Upstream product

• 7315-17-5 3-(2-chloro-phenyl)-propionitrile 
• 5259-97-2 [1,3]oxazinan-2-one 
• 108-90-7 chlorobenzene 
• 64-19-7 acetic acid 
• 74738-21-9 3-(2'-chlorophenyl)-2-propenenitrile 
• 2038-57-5 3-Phenylpropan-1-amine 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 
• 134306-93-7 3-(2-chlorophenyl)propionamide 

Downstream Products

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 148717-49-1 N-[3-(2-chlorophenyl)propyl]-R-α-methyl-3-methoxybenzylamine 
• 189289-49-4 [3-(2-Chloro-phenyl)-propyl]-[1-(3-methoxy-phenyl)-eth-(E)-ylidene]-amine 
• 148717-49-1 tecalcet 
• 148717-49-1 NPS-S 568 
• 177172-49-5 Tecalcet hydrochloride 

Relevant articles and documents

TERTIARY AMIDES AND METHOD OF USE

Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane

A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.

Synthesis and biological activity of allosteric modulators of GABA B receptors, Part 1. N-(Phenylpropyl)-1-arylethylamines

A series of 15 analogues of fendiline, and 34 derivatives of N-(3-phenylpropyl)-1-arylethylamine have been prepared for evaluation as positive allosteric modulators of GABAB receptors. The most active (EC50, 10 nM) was N-(3,3-diphenylpropyl)-1-(3-chloro-4-methoxyphenyl) ethylamine 6g. CSIRO 2006.