186590-01-2 Usage
Description
4-fluoro-2-hydroxybenzonitrile, also known as 2-Cyano-5-fluorophenol, is an organic compound with a molecular formula of C7H4FNO. It features a benzene ring with a fluorine atom at the 4-position, a hydroxyl group at the 2-position, and a nitrile group attached to the same carbon as the hydroxyl group. This unique structure endows it with specific chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Research:
4-fluoro-2-hydroxybenzonitrile is used as a research compound for studying the substituent effect on fluorobenzene derivatives. Specifically, it is employed to investigate the impact of different substituents on the cytochrome P450-catalyzed hydroxylation at the adjacent ortho aromatic carbon center. This research is crucial for understanding the metabolism and biotransformation of fluorinated compounds, which can lead to the development of more effective and safer pharmaceuticals.
Used in Chemical Synthesis:
Due to its unique structure, 4-fluoro-2-hydroxybenzonitrile can be used as a building block or intermediate in the synthesis of various organic compounds. Its presence of a nitrile group makes it a versatile starting material for the preparation of amines, amides, and other nitrogen-containing compounds. Additionally, the hydroxyl and fluorine substituents can be utilized for further functionalization and modification of the molecule, expanding its potential applications in the chemical industry.
Used in Material Science:
The distinct electronic and steric properties of 4-fluoro-2-hydroxybenzonitrile can make it a valuable component in the development of new materials with specific properties. For instance, it can be incorporated into polymers to create materials with tailored characteristics, such as improved thermal stability, enhanced solubility, or altered optical properties. Furthermore, its potential use in the synthesis of novel coordination compounds or metal-organic frameworks could lead to advances in areas like catalysis, gas storage, or sensing.
Check Digit Verification of cas no
The CAS Registry Mumber 186590-01-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,5,9 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 186590-01:
(8*1)+(7*8)+(6*6)+(5*5)+(4*9)+(3*0)+(2*0)+(1*1)=162
162 % 10 = 2
So 186590-01-2 is a valid CAS Registry Number.
186590-01-2Relevant articles and documents
Lewis acid-promoted site-selective cyanation of phenols
Yang, Wen,Zhang, Wu,Zhao, Wanxiang
supporting information, p. 4604 - 4609 (2020/07/04)
An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.
HIV integrase inhibitors
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Page/Page column 33, (2010/11/27)
The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
PHENYL- AND PYRIDYL-I, 2 , 4 -OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
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Page/Page column 157-158, (2008/06/13)
The invention relates to phenyl-1,2,4-oxadiazolone derivatives with phenyl group and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity. What is described are compounds of the formula (I) in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
