186593-56-6

Basic information

• Product Name: 1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, phenylmethyl ester, (2S)-
• CAS NO: 186593-56-6
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol File: 186593-56-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, phenylmethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, phenylmethyl ester, (2S)-(186593-56-6)
• EPA Substance Registry System: 1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, phenylmethyl ester, (2S)-(186593-56-6)

Safety Data

• Hazardous Substances Data: 186593-56-6(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 104587-62-4 (S)-azetidine-2-methanol 
• 155878-39-0 (S)-4-isopropoxycarbonyl-2-azetidinone 
• 677-22-5 tert-butylmagnesium chloride 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 25654-52-8 (2S)-1-(benzyloxycarbonyl)azetidine-2-carboxylic acid 
• 144062-00-0 N-benzyloxycarbonyl azetidine-2-carboxylate methyl ester 

Downstream Products

• 186593-24-8 2-Fluoro-3-(1-Cbz-2-(S)-azetidinylmethoxy)pyridine 
• 25654-52-8 (2S)-1-(benzyloxycarbonyl)azetidine-2-carboxylic acid 
• 186593-51-1 6-fluoro-5-methyl-3-(1-benzyloxycarbonyl-(2S)-azetidinylmethoxy)pyridine 
• 195607-11-5 (S)-2-(Bis-ethylsulfanyl-methyl)-azetidine-1-carboxylic acid benzyl ester 
• 477585-96-9 (2R)-3-((1-benzyloxycarbonyl)azetidin-2-yl)propanoic acid 
• 477585-76-5 methyl (2R)-3-((1-benzyloxycarbonyl)azetidin-2-yl)propanoate 
• 477585-75-4 (S)-2-((E)-2-Methoxycarbonyl-vinyl)-azetidine-1-carboxylic acid benzyl ester 
• 228867-83-2 (S)-1-(benzyloxycarbonyl)-2-azetidinemethanol-p-tosylate 
• 195607-10-4 (S)-2-Formyl-azetidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

AZETIDOBENZODIAZEPINE DIMERS AND CONJUGATES COMPRISING THEM FOR USE IN THE TREATMENT OF CANCER

A compound of formula IV: as well as drug-linkers and conjugates comprising this compound, and the use of the conjugates in treating cancer.

Synthesis of a new precursor to the nicotinic receptor tracer 5-IA-85380 precursor using trimethylsilyl iodide as deblocking agent

We describe the synthesis of a new precursor of 5-IA-85380, specific radiotracer for α4β2 nicotinic acetylcholine receptors. (S)-5-Trimethylstannyl-3-(2-azetidinylmethoxy)pyridine (4) was prepared in six steps and 62% overall yield starting from (S)-2- azetidinecarboxylic acid. The key step of this synthesis is selective release of the amine function without removing the stannyl moiety using trimethylsilyl iodine.

Processes for producing azetidine-2-carboxylic acid and intermediates thereof

PCT No. PCT/JP98/01895 Sec. 371 Date Dec. 30, 1999 Sec. 102(e) Date Dec. 30, 1999 PCT Filed Apr. 24, 1998 PCT Pub. No. WO98/47867 PCT Pub. Date Oct. 29, 1998The present invention has its object to provide a process for producing azetidine-2-carboxylic acid and an intermediate thereof, which is efficient and economical and suited for industrial practice. The present invention is related to a process for producing azetidine-2-carboxylic acid of the following formula (5), which comprises subjecting a 4-oxo-2-azetidinecarboxylic acid derivative represented by the general formula (1) to hydride reduction to give azetidine-2-methanol of the following formula (2), treating the same with an amino-protecting agent to give N-protected azetidine-2-methanol represented by the following general formula (3), treating this with an oxidizing agent to give N-protected azetidine-2-carboxylic acid represented by the following general formula (4) and, further, subjecting the amino-protecting group thereof to elimination.