186665-89-4Relevant articles and documents
Electrochemically induced fluorinative ring expansion of cycloalkylideneacetates
Hara, Shoji,Chen, Sheng-Qi,Hoshio, Takuro,Fukuhara, Tsuyoshi,Yoneda, Norihiko
, p. 8511 - 8514 (1996)
The electrochemical oxidation of cyclic unsaturated esters (1) was carried out using ET3N-5HF as the electrolyte. The ring expansion and fluorination took place to give β,β-difluorocycloalkanecarboxylic esters (2) selectively.
A general route for the synthesis of β,β-difluorocarboxylic acids
Cohen, Or,Rozen, Shlomo
, p. 5362 - 5364 (2008/12/20)
A new method for the preparation of β,β-difluoro- (and other gem-difluoro) acids has been developed. It is based on the fact that 3-oxocarboxylic esters are easy to make and convert to the corresponding dithiane derivatives. These dithianes reacted with B
