18671-02-8

Basic information

• Product Name: Boc-Asp(OBzl)-Ala-OBzl
• Synonyms: Boc-Asp(OBzl)-Ala-OBzl
• CAS NO: 18671-02-8
• Molecular Weight: 484.549
• Mol File: 18671-02-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Boc-Asp(OBzl)-Ala-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Asp(OBzl)-Ala-OBzl(18671-02-8)
• EPA Substance Registry System: Boc-Asp(OBzl)-Ala-OBzl(18671-02-8)

Safety Data

• Hazardous Substances Data: 18671-02-8(Hazardous Substances Data)

Upstream product

• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 42854-62-6 L-alanine benzyl ester p-toluenesulfonate 
• 17831-01-5 H-Ala-OBzl 

Downstream Products

• 77935-54-7 ((2S,5S)-5-Methyl-3,6-dioxo-piperazin-2-yl)-acetic acid benzyl ester 

Relevant articles and documents

The hydrolysis of primary amide groups in Asn/Gln-containing peptides

Peptides Boc-Ala-Asn/Gln-OH and Boc-Asn/Gln-Ala-OH were saponified with barium hydroxide to corresponding Asp/Glu-containing peptides. Under the conditions of saponification, Boc-Asn-Ala-OH additionally afforded Boc-Asp-OH, isopeptide Boc-Asp(Ala)-OH, and Boc-NHSuc > Ala-OH, with the third being the key intermediate in these transformations. Boc-Asp(OMe)-Ala-OMe underwent similar transformations under treatment with diazomethane or triethylamine. Saponification with barium hydroxide was accompanied by a high epimerization of N-terminal amino acid residues, whereas the products of the diazomethane treatment of Boc-Asp(OMe)-Ala-OMe had a low degree of epimerization.