18672-04-3

Basic information

• Product Name: ETHYL 2-METHYL-2-PHENOXYPROPANOATE
• Synonyms: ETHYL 2-METHYL-2-PHENOXYPROPANOATE
• CAS NO: 18672-04-3
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25
• Product Categories: pharmacetical
• Mol File: 18672-04-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 271.9°Cat760mmHg
• Flash Point: 108.6°C
• Appearance: /
• Density: 1.043g/cm³
• Vapor Pressure: 0.00626mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: ETHYL 2-METHYL-2-PHENOXYPROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-METHYL-2-PHENOXYPROPANOATE(18672-04-3)
• EPA Substance Registry System: ETHYL 2-METHYL-2-PHENOXYPROPANOATE(18672-04-3)

Safety Data

• Hazardous Substances Data: 18672-04-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16O3/c1-4-14-11(13)12(2,3)15-10-8-6-5-7-9-10/h5-9H,4H2,1-3H3

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 139-02-6 sodium phenoxide 
• 64-17-5 ethanol 
• 943-45-3 2-methyl-2-phenoxypropionic acid 
• 108-95-2 phenol 
• 67-66-3 chloroform 
• 67-64-1 acetone 
• 57-15-8 1,1,1-trichloro-2-methyl-2-propanol 
• 637-07-0 Clofibrate 
• 80-55-7 ethyl 2-hydroxy-2,2-dimethylethanoate 
• 28899-97-0 triphenylbismuth(V) diacetate 
• 584-08-7 potassium carbonate 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 

Downstream Products

• 943-45-3 2-methyl-2-phenoxypropionic acid 
• 113511-46-9 α-phenoxy-isobutyrohydroxamic acid 
• 60277-50-1 2-{4'-[2-(2-Methoxy-benzoylamino)-ethyl]-biphenyl-4-yloxy}-2-methyl-propionic acid ethyl ester 
• 60277-39-6 ethyl 2-methyl 2-{4-[-2-(2-methoxy-5-chloro-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate 
• 62734-46-7 ethyl 2-[4-(bromoacetyl)phenoxy]-2-methylpropionate 
• 167213-40-3 ethyl 2-[4-(2-bromoethyl)phenoxy]-2-methylpropionate 
• 247073-81-0 ethyl 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionate 
• 10514-70-2 2,2-dimethyl-2H-1,4-benzoxazine-3-one 
• 10514-62-2 2-Methyl-2-(2-nitrophenoxy)propanoic Acid 
• 60277-46-5 2-Methyl-2-{4-[2(2-methoxy-5-chloro-benzamido)-ethyl]-biphenyl-4'-oxy}-propanol 
• 60302-51-4 2-Methyl-2-{4-[2-(2-methoxy-5-chloro-benzamido)-ethyl]biphenyl-4'-oxy}-propionic acid 
• 444613-22-3 2-methyl-2-(4-sulfophenoxy)propionic acid ethyl ester 
• 444613-21-2 ethyl 2-[4-(chlorosulfonyl)phenoxy]-2-methylpropanoate 
• 16748-90-6 2,2-dimethylbenzofuran-3(2H)-one 

Relevant articles and documents

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

A novel organic electron donor derived from N-methylisatin

We report the reactivity of an electron donor derived from N-methylisatin on reduction by sodium amalgam. Transfer of a clear supernatant solution to iodoarenes affords the products of two-electron reduction. Reductions of sulfones, activated arenesulfonamides, and Weinreb amides are also reported.

Super-electron donors: Bis-pyridinylidene formation by base treatment of pyridinium salts

Deprotonation of bispyridinium salt 7b affords bispyridinylidene 10, a very powerful neutral organic two-electron donor [E1/2 (DMF) = -1.13 V vs Ag/AgCI/KCI (sat)], presumably via the pyridinylidene 8. Donor 10 reduces aryl iodides and bromides to aryl anions in excellent yield and also reductively cleaves selected phenylalkylsulfones very efficiently.