18677-48-0

Basic information

• Product Name: 3,5-Dimethoxypyridine
• Synonyms: 3,5-Dimethoxypyridine;Pyridine, 3,5-diMethoxy-
• CAS NO: 18677-48-0
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.15
• EINECS: -0
• Product Categories: API intermediates;Pyridines;Aromatics;Bases & Related Reagents;Nucleotides
• Mol File: 18677-48-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 225.615 °C at 760 mmHg
• Flash Point: 81.985 °C
• Appearance: Colorless to pale yellow oil
• Density: 1.065 g/cm³
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: 4.00±0.10(Predicted)
• CAS DataBase Reference: 3,5-Dimethoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethoxypyridine(18677-48-0)
• EPA Substance Registry System: 3,5-Dimethoxypyridine(18677-48-0)

Safety Data

• Hazardous Substances Data: 18677-48-0(Hazardous Substances Data)

Usage

Description

3,5-Dimethoxypyridine, with the CAS number 18677-48-0, is an organic compound characterized by its colorless to pale yellow oily appearance. It is primarily utilized in the field of organic synthesis, playing a significant role in the creation of various chemical compounds and materials.

Uses

Used in Organic Synthesis:
3,5-Dimethoxypyridine is used as a synthetic building block for the development of a wide range of chemical compounds. Its unique structure and functional groups make it a valuable component in the synthesis of various organic molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,5-Dimethoxypyridine is used as an intermediate in the synthesis of various drugs and drug candidates. Its presence in the molecular structure can contribute to the desired biological activity, making it a crucial component in the development of new medications.
Used in Agrochemical Industry:
3,5-Dimethoxypyridine also finds application in the agrochemical industry, where it is used as a starting material for the synthesis of various agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in protecting crops and controlling pests.
Used in Specialty Chemicals:
In the specialty chemicals sector, 3,5-Dimethoxypyridine is employed as a key component in the synthesis of specific chemicals with unique properties. These specialty chemicals can be used in various applications, such as dyes, additives, and advanced materials, where their distinct characteristics are highly valued.

InChI:InChI=1/C7H9NO2/c1-9-6-3-7(10-2)5-8-4-6/h3-5H,1-2H3

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 124-41-4 sodium methylate 
• 2457-47-8 3,5-dichloropyridine 
• 865-33-8 potassium methanolate 
• 84476-99-3 2,5-difluoropyridine 
• 71902-33-5 3,5-difluoropyridine 
• 67-56-1 methanol 

Downstream Products

• 875152-71-9 2-(3,5-dimethoxy-benzyl)-5-isobutoxy-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 1228631-19-3 benzyl 3,5-dioxopiperidine-1-carboxylate 
• 396090-17-8 prop-2-enyl 5-hydroxy-3-oxo-1,2,6-trihydropyridine-1-carboxylate 
• 811450-68-7 N-(1,2,5,6-tetrahydro-5-oxopyridin-3-yl)-L-phenylalanine methyl ester 
• 811450-57-4 N-(1-(benzyloxycarbonyl)-1,2,5,6-tetrahydro-5-oxopyridin-3-yl)-L-phenylalanine 
• 396090-39-4 Ach-Phe t-butyl ester 
• 396090-18-9 prop-2-enyl 3-oxo-5-[(2,4,6-trimethylphenyl)sulfonyloxy]-1,2,6-trihydropyridine-1-carboxylate 
• 396090-35-0 tert-butyl (2S)-2-{[5-oxo-1-(prop-2-enyloxycarbonyl)-1,2,6-trihydro-3-pyridyl]amino}-3-phenylpropanoate 
• 396090-42-9 Ac-Phe-Ach-Leu-Ach-Ile 
• 396090-41-8 Ac-Phe-Ach-Leu-Ach-Ile tert-butyl ester 

Relevant articles and documents

An improved procedure for the synthesis of enaminones - Dimer building blocks in β-strand mimetics

@-Tides have been shown to have the same characteristics as a peptide in the β-strand conformation and to have the ability to self-associate into dimeric β-sheets. Aza-cyclohexaenaminones, obtained by condensation of a protected azacyclohexa-3,5-dione and amino acid esters, are the key building-blocks in the synthesis of @-tides. An improved three-step synthetic sequence to these enaminones has been developed that takes advantage of microwave-assisted chemistry in two of the steps to enhance the reaction rates. It was also found that the enaminone building blocks can be obtained by direct condensation of the aza-cyclohexa-3,5-dione with amino acid esters, without prior activation of the diketone. Multivariate design was used to optimize this microwave-assisted condensation, resulting in a short reaction time (300 s) and high yields (67-94%). Georg Thieme Verlag Stuttgart.

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions. Unlike earlier allosteric activators that bind covalently to hemoglobin in a 2:1 stoichiometry, 36 binds with a 1:1 stoichiometry. Compound 36 is orally bioavailable and partitions highly and favorably into the red blood cell with a RBC/plasma ratio of ～150. This partitioning onto the target protein is anticipated to allow therapeutic concentrations to be achieved in the red blood cell at low plasma concentrations. GBT440 (36) is in Phase 3 clinical trials for the treatment of sickle cell disease (NCT03036813).

SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.