186817-88-9Relevant articles and documents
Practical synthesis of anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem L-742,728
Yasuda, Nobuyoshi,Huffman, Mark A.,Ho, Guo-Jie,Xavier, Lyndon C.,Yang, Chunhua,Emerson, Khateeta M.,Tsay, Fuh-Rong,Li, Yulan,Kress, Michael H.,Rieger, Dale L.,Karady, Sandor,Sohar, Paul,Abramson, Newton L.,DeCamp, Ann E.,Mathre, David J.,Douglas, Alan W.,Dolling, Ulf-H.,Grabowski, Edward J. J.,Reider, Paul J.
, p. 5438 - 5446 (1998)
Anti-MRSA carbapenem, L-742,728, has been prepared in large quantity using the Suzuki-Miyaura cross-coupling as the key reaction. Three approaches have been examined by varying the coupling reaction between carbapenem nucleus A and side chains B, BC, and