18684-09-8

Basic information

• Product Name: Benzenesulfonic acid, 2-methyl-, hydrazide
• CAS NO: 18684-09-8
• Molecular Formula: C7H10N2O2S
• Molecular Weight: 186.235
• Mol File: 18684-09-8.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Benzenesulfonic acid, 2-methyl-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid, 2-methyl-, hydrazide(18684-09-8)
• EPA Substance Registry System: Benzenesulfonic acid, 2-methyl-, hydrazide(18684-09-8)

Safety Data

• Hazardous Substances Data: 18684-09-8(Hazardous Substances Data)

Upstream product

• 133-59-5 Toluene-2-sulfonyl chloride 

Downstream Products

• 56776-55-7 N-phenyl-S-(2-methylphenyl) sulfonamide 
• 1616956-06-9 2-methylphenyl cyclopentyl sulfide 
• 1616956-04-7 2-methylphenyl cyclooctyl sulfide 
• 59693-92-4 cyclohexyl 2-methylphenyl sulfide 
• 605-39-0 2,2'-dimethyl-1,1'-biphenyl 
• 57132-25-9 4-(2-methylphenyl)butan-2-one 
• 32959-60-7 2-(2-methylphenyl)-1,3-benzoxazole 
• 1137486-72-6 1,3,7-trimethyl-8-(o-tolyl)-xanthine 
• 1613250-56-8 3,5-dimethyl-1,4-bis(o-tolylsulfonyl)-1H-pyrazole 
• 33667-81-1 mesityl(o-tolyl)sulfane 
• 7305-14-8 S-o-tolyl dimethylcarbamothioate 
• 23276-69-9 1-methyl-2-(methylsulfonyl)benzene 

Relevant articles and documents

Iodine-catalyzed expeditious synthesis of sulfonamides from sulfonyl hydrazides and amines

A new synthesis of sulfonamides has been developed via an iodine-catalyzed sulfonylation of amines with arylsulfonyl hydrazides. This metal-free strategy employs readily accessible and easy to handle starting materials, catalysts and oxidants, and can be easily conducted under mild conditions, providing a convenient access to a wide range of sulfonamides in moderate to excellent yields within a short reaction time.

Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols

An unprecedented electrochemical heterodifunctionalization of α-CF3alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.

Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives

An efficient iodine-mediated coupling of cyclic amines with sulfonyl hydrazides is reported. This transformation opens a new route to the synthesis of vinyl sulfones derivatives, which is a common structural motif in natural products and pharmaceuticals. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.