18686-82-3

Basic information

• Product Name: 2-Mercapto-1,3,4-thiadiazol
• Synonyms: MTD;2-mercapto-1,3,4-thiadiazol;2-MERCAPTO-1,3,4-THIADIAZOLE;2-MEREAPTO-1,3,4-THIADIAZOLE;1,3,4-THIADIAZOL-2-YL HYDROSULFIDE;1,3,4-THIADIAZOLE-2-THIOL;AKOS TOT-0656;AKOS BBS-00004641
• CAS NO: 18686-82-3
• Molecular Formula: C₂H₂N₂S₂
• Molecular Weight: 118.18
• EINECS: 242-504-5
• Product Categories: chemical;pharmaceutical intermediate
• Mol File: 18686-82-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 142-144°C
• Boiling Point: 176 °C at 760 mmHg
• Flash Point: 60.3 °C
• Appearance: White to slightly yellow crystalline powder
• Density: 1.73 g/cm³
• Vapor Pressure: 1.11mmHg at 25°C
• Refractive Index: 1.849
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Soluble in methanol.
• PKA: 6.45±0.20(Predicted)
• CAS DataBase Reference: 2-Mercapto-1,3,4-thiadiazol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Mercapto-1,3,4-thiadiazol(18686-82-3)
• EPA Substance Registry System: 2-Mercapto-1,3,4-thiadiazol(18686-82-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37-37/39
• TSCA: Yes
• Hazardous Substances Data: 18686-82-3(Hazardous Substances Data)

Usage

Description

2-Mercapto-1,3,4-thiadiazol is a heterocyclic compound characterized by the presence of a sulfur atom and a thiazole ring. It is a white to light yellow crystalline powder with unique chemical properties that make it a valuable intermediate in the synthesis of various pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
2-Mercapto-1,3,4-thiadiazol is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows it to be incorporated into a wide range of therapeutic agents, enhancing their efficacy and pharmacological properties.
Used in Ceftezole Thiazole:
2-Mercapto-1,3,4-thiadiazol is used as a key component in the synthesis of ceftezole thiazole, a broad-spectrum antibiotic. Its presence in the molecule contributes to the drug's effectiveness against a variety of bacterial infections, making it a valuable asset in the treatment of different medical conditions.

InChI:InChI=1/C2H2N2S2/c5-2-4-3-1-6-2/h1H,(H,4,5)

Upstream product

• 61929-24-6 2-bromo-1,3,4-thiadiazole 
• 17356-08-0 thiourea 
• 70028-72-7 C₂H₃N₂OS₂^(1-)*K⁽¹⁺⁾ 
• 4005-51-0 [1,3,4]Thiadiazol-2-ylamin 
• 56366-87-1 CH₄N₂S₂*C₆H₁₅N 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 289-06-5 1,3,4-thiadiazole 
• 156662-53-2 p-nitrobenzyl (6S,7S)-7-(4-nitrophthalimido)-8-oxo-3-<(1,3,4-thiadiazol-2-yl)thiomethyl>-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate 
• 136248-52-7 (6S,7S)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-3-([1,3,4]thiadiazol-2-ylsulfanylmethyl)-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 220430-19-3 benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-(1,3,4-thiadiazol-2-yl)thiomethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate 
• 220430-32-0 benzhydryl (1S,5R,6S)-1-(4-tert-butoxycarbonylaminobutyl)-2-(1,3,4-thiadiazol-2-yl)thiomethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate 
• 179034-67-4 benzhydryl 7β-(2-phenylacetamido)-3-(1,3,4-thiadiazol-2-yl)thio-3-cephem-4-carboxylate 
• 666752-72-3 2-[[(3-chlorophenyl)methyl]thio]-6-[[(1R)2-hydroxy-1-methylethyl]amino]-5-(1,3,4-thiadiazol-2-ylthio)-4-pyrimidinol 
• 752242-33-4 5-isopropoxy-3-(1,3,4-thiadiazol-2-yl-thio)benzoic acid methyl ester 

Relevant articles and documents

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Thiadiazole Which can be used as a Vulcanization Accelerator and Method for Obtaining Same

A thiadiazole of formula (I):

Acylamino-cephem-carboxylic acids containing an amidino or guanidino group in the molecule

Acylamino-cephem-carboxylic acids of the formula I STR1 in which R1, R2 and R3 represent hydrogen or alkyl, R1 and R2 or R2 and R3 together may form an alkylene radical which may be substituted, X represents a single bond or NH, A represents a phenylene or thienylene radical which may be substituted, Y represents a single bond or oxygen and Z represents a 5- or 6-membered ring which may be substituted and which may be bound to an anellated ring system, and their physiologically tolerated salts and esters, a process for preparing these compounds and preparations containing them.