18708-16-2

Basic information

• Product Name: Benzenesulfonicacid, 4-methyl-, 2-[[4-(dimethylamino)phenyl]methylene]hydrazide
• Synonyms: Benzenesulfonicacid, 4-methyl-, [[4-(dimethylamino)phenyl]methylene]hydrazide (9CI);p-Toluenesulfonic acid, [p-(dimethylamino)benzylidene]hydrazide (7CI,8CI); NSC269430
• CAS NO: 18708-16-2
• Molecular Formula: C16H19 N3 O2 S
• Molecular Weight: 317.412
• Mol File: 18708-16-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 482.6°Cat760mmHg
• Flash Point: 245.7°C
• Density: 1.17g/cm³
• CAS DataBase Reference: Benzenesulfonicacid, 4-methyl-, 2-[[4-(dimethylamino)phenyl]methylene]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonicacid, 4-methyl-, 2-[[4-(dimethylamino)phenyl]methylene]hydrazide(18708-16-2)
• EPA Substance Registry System: Benzenesulfonicacid, 4-methyl-, 2-[[4-(dimethylamino)phenyl]methylene]hydrazide(18708-16-2)

Safety Data

• Hazardous Substances Data: 18708-16-2(Hazardous Substances Data)

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 120434-31-3 4-((9H-xanthen-9-ylidene)methyl)-N,N-dimethylaniline 
• 2871-86-5 4-((9H-fluoren-9-ylidene)methyl)-N,N-dimethylaniline 
• 81162-82-5 1-4-(dimethylamino)benzene 
• 474661-33-1 N,N-dimethyl-4-(prop-1-yn-1-yl)aniline 
• 86448-32-0 N,N-dimethyl-4-(propa-1,2-dien-1-yl)aniline 
• 19293-58-4 (4-aminomethylphenyl)dimethylamine 

Relevant articles and documents

Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles

Intermolecular cycloaddition of tosylhydrazones with nitriles was investigated. t -BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol, and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H -1,2,3-triazoles were prepared in good to excellent yields and with high purities. The process is azide-free and transition-metal-free.

Highly stereoselective synthesis of 1-cyanocyclopropane-carboxamides from 3-substituted-2-cyanoacrylamides with N-tosylhydrazones under metal-free conditions

A metal-free cyclopropanation of electron-deficient olefins 3-substituted-2-cyanoacrylamides with N-tosylhydrazones has been successfully developed. This strategy provide a simple route to the synthesis of very valuable 1-cyanocyclopropanecarboxamides wit

Pd-Catalyzed Highly Regio- and Stereoselective Formation of C-C Double Bonds: An Efficient Method for the Synthesis of Benzofuran-, Dihydrobenzofuran-, and Indoline-Containing Alkenes

A highly regio- and stereoselective C-C double bond formation reaction via Pd-catalyzed Heck-type cascade process with N-tosylhydrazones has been developed. Various N-tosylhydrazones derived from both ketones and aldehydes are found to be efficient substrates to provide di- and trisubstituted olefins with high regio- and stereoselectivity. Furthermore, this reaction has a good functional group tolerance and different benzofuran-, dihydrobenzofuran-, and indoline-containing alkene products were obtained with high selectivity.