187173-05-3 Usage
Description
2-(4,5-Dihydroimidaazol-2-yl)quinoline hydrochloride, also known as BU224, is a chemical compound that serves as a ligand for the I2 receptors. It is characterized by its imidazoquinoline structure and hydrochloride salt form, which contributes to its biological activity and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
2-(4,5-Dihydroimidaazol-2-y)quinoline hydrochloride is used as a receptor ligand for the I2 receptors, which are involved in various physiological processes. Its interaction with these receptors has been found to have potential therapeutic applications.
Used in Pain Management:
In the field of pain management, BU224 is used as an antinociceptive agent for the treatment of pain. Its action on the I2 receptors helps in reducing pain perception and providing relief to patients suffering from various types of pain.
Used in Psychiatry:
2-(4,5-Dihydroimidaazol-2-yl)quinoline hydrochloride is also used as an antidepressant-like agent in rodents. Its interaction with the I2 receptors may contribute to the modulation of mood and the alleviation of depressive symptoms, making it a potential candidate for the development of new antidepressant medications.
Biological Activity
High affinity ligand for the imidazoline I 2 binding site (K i = 2.1 nM). Putative I 2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
Check Digit Verification of cas no
The CAS Registry Mumber 187173-05-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,1,7 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 187173-05:
(8*1)+(7*8)+(6*7)+(5*1)+(4*7)+(3*3)+(2*0)+(1*5)=153
153 % 10 = 3
So 187173-05-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H11N3.ClH/c1-2-4-10-9(3-1)5-6-11(15-10)12-13-7-8-14-12;/h1-6H,7-8H2,(H,13,14);1H
187173-05-3Relevant articles and documents
Iridium-catalyzed chemoselective transfer hydrogenation of α, β-unsaturated ketones to saturated ketones in water
Chen, Jinxun,Chen, Yongsheng,Cui, Xiaofeng,Jiang, Xiaolan,Liu, Qixing,Zhou, Haifeng
supporting information, (2022/01/24)
A chemoselective iridium-catalyzed transfer hydrogenation of α, β-unsaturated ketones was realized in water. The C[dbnd]C double bonds of 2-benzylidene indanones and analogues were hydrogenated exclusively catalyzed by an iridium complex (0.1 mol%) bearin
Ultrasound promoted synthesis of 2-imidazolines in water: A greener approach toward monoamine oxidase inhibitors
Sant' Anna, Gabriela da S.,Machado, Pablo,Sauzem, Patricia D.,Rosa, Fernanda A.,Rubin, Maribel A.,Ferreira, Juliano,Bonacorso, Helio G.,Zanatta, Nilo,Martins, Marcos A.P.
experimental part, p. 546 - 549 (2011/03/19)
A series of sixteen 2-substituted-2-imidazolines (where the substituent R = Ph, Me-4-Ph; MeO-4-Ph; (MeO)2-3,4-Ph; (MeO)3-3,4,5-Ph; Ph-4-O-C(O)-Ph; Cl-4-Ph; Cl-2-Ph; Cl2-2,4-Ph; NO2-4-Ph; NO2-3-Ph; Naphth-2-yl; Fur-2-yl; Benzofur-2-yl; Pyridin-2-yl; Quinolin-2-yl) has been synthesized from the reaction of the substituted-aldehydes and ethylenediamine by ultrasound irradiation with NBS in an aqueous medium in high yields (80-99%). The 2-imidazoline ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO) was investigated and some of them showed potent and selective MAO inhibitory activity especially for the MAO-B isoform and could become promising candidates for future development.