187224-29-9 Usage
Description
ARA-S, or N-Arachidonoyl-L-serine, is a recently isolated endocannabinoid with an unusual activity profile. It does not bind to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors or vanilloid receptor 1 (VR1). ARA-S exhibits neuroprotective, pro-angiogenic, and vasodilatory properties, making it a promising candidate for various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
ARA-S is used as a neuroprotective agent for its ability to exhibit neuroprotection via ERK and Akt phosphorylation and induction of their downstream antiapoptotic pathways. This makes it a potential candidate for treating conditions associated with neuronal damage or degeneration.
Used in Cardiovascular Applications:
ARA-S is used as a vasodilator for its ability to relax isolated rat mesenteric arteries and abdominal aorta. This property can be beneficial in treating conditions related to vascular constriction and hypertension.
Used in Angiogenesis Research:
ARA-S is used as a pro-angiogenic factor for its ability to promote the formation of new blood vessels. This characteristic can be useful in wound healing, tissue regeneration, and other applications where new blood vessel formation is desired.
Used in Traumatic Brain Injury Treatment:
ARA-S is used as a proneurogenic agent in vitro and in vivo in mice models of traumatic brain injury. Its neuroprotective and pro-angiogenic properties make it a potential therapeutic option for treating brain injuries and promoting neural regeneration.
Check Digit Verification of cas no
The CAS Registry Mumber 187224-29-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,2,2 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 187224-29:
(8*1)+(7*8)+(6*7)+(5*2)+(4*2)+(3*4)+(2*2)+(1*9)=149
149 % 10 = 9
So 187224-29-9 is a valid CAS Registry Number.
187224-29-9Relevant articles and documents
Identification of endogenous acyl amino acids based on a targeted lipidomics approach
Tan, Bo,O'Dell, David K.,Yu, Y. William,Monn, M. Francesca,Hughes, H. Velocity,Burstein, Sumner,Walker, J. Michael
experimental part, p. 112 - 119 (2010/11/03)
Using a partially purified bovine brain extract, our lab identified three novel endogenous acyl amino acids in mammalian tissues. The presence of numerous amino acids in the body and their ability to form amides with several saturated and unsaturated fatty acids indicated the potential existence of a large number of heretofore unidentified acyl amino acids. Reports of several additional acyl amino acids that activate G-protein coupled receptors (e.g., N-arachidonoyl glycine, N- arachidonoyl serine) and transient receptor potential channels (e.g., N-arachidonoyl dopamine, N-acyl taurines) suggested that some or many novel acyl amino acids could serve as signaling molecules. Here, we used a targeted lipidomics approach including specific enrichment steps, nano-LC/MS/MS, high-throughput screening of the datasets with a potent search algorithm based on fragmention analysis, and quantification using the multiple reaction monitoring mode in Analyst software to measure the biological levels of acyl amino acids in rat brain. We successfully identified 50 novel endogenous acyl amino acids present at 0.2 to 69 pmol g-1 wet rat brain. Copyright
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor
Sheskin, Tzviel,Hanu?, Lumir,Slager, Joram,Vogel, Zvi,Mechoulam, Raphael
, p. 659 - 667 (2007/10/03)
In order to establish the structural requirements for binding to the brain cannabinoid receptor (CB1), we have synthesized numerous fatty acid amides, ethanolamides, and some related simple derivatives and have determined their K(i) values. A f
