18731-19-6

Basic information

• Product Name: 2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE
• Synonyms: 2,6-DIMETHYL-3H-QUINAZOLINE-4-ONE;2,6-Dimethyl-4(1H)-quinazolinone;2,6-DiMethylquinazolin-4(1H)-one;2,6-Dimethyl-4(3H)-quinazolinone;Raltitrexed Impurity 2
• CAS NO: 18731-19-6
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Mol File: 18731-19-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 330 °C
• Boiling Point: 336.6 °C at 760 mmHg
• Flash Point: 157.4 °C
• Appearance: /
• Density: 1.23 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.97±0.20(Predicted)
• CAS DataBase Reference: 2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE(18731-19-6)
• EPA Substance Registry System: 2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE(18731-19-6)

Safety Data

• Hazardous Substances Data: 18731-19-6(Hazardous Substances Data)

Usage

General Description

2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE is a chemical compound with a quinazoline ring structure and two methyl groups attached to the 2 and 6 positions. It is commonly used as a building block in the synthesis of pharmaceuticals and organic compounds. 2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE has been studied for its potential biological and pharmacological activities, including its antitumor and antibacterial properties. Additionally, 2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE has been investigated for its potential use as a fluorescent probe in analytical chemistry. Overall, this chemical compound has diverse applications in the field of medicinal chemistry and drug discovery.

Upstream product

• 16499-40-4 2,6-dimethyl-quinazoline 
• 103-89-9 4-Methylacetanilide 
• 51-79-6 urethane 
• 67081-68-9 2-acetamido-5-methylbenzoic acid 
• 2050-43-3 N-(2,4-dimethylphenyl)acetamide 
• 108-24-7 acetic anhydride 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 62-55-5 thioacetamide 
• 62175-49-9 2-methyl-6-methyl-4H-3,1-benzoxazin-4-one 
• 1224442-42-5 C₁₀H₁₁N₃O₃ 
• 52548-14-8 2-iodoyl-5-methylbenzoic acid 
• 124-42-5 acetamidine hydrochloride 
• 6967-82-4 2-bromo-5-methylbenzoic acid 
• 40545-33-3 2-amino-5-methylbenzamide 

Downstream Products

• 112888-43-4 4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline 
• 112887-62-4 N-p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl-L-glutamic acid 
• 133933-15-0 2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideaza-1,2-dihydrofolic acid 
• 133933-32-1 diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate 
• 112887-84-0 (S)-2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(2-oxo-propyl)-amino]-benzoylamino}-pentanedioic acid 

Relevant articles and documents

Improved synthesis of 3,4-dihydro-2,6-dimethyl-4-oxoquinazoline

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Cp?CoIII-catalyzed formal [4+2] cycloaddition of benzamides to afford quinazolinone derivatives

A Cp?CoIII-catalyzed arene C-H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope. This method could be applied to the synthesis of quinazolinone drugs and late-stage modification of natural products.

ANTIBIOTICS EFFECTIVE FOR GRAM-NEGATIVE PATHOGENS

Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative