187325-53-7

Basic information

• Product Name: (Z)-3-((pyridin-2-yl)methylene)indolin-2-one
• CAS NO: 187325-53-7
• Molecular Weight: 222.246
• Mol File: 187325-53-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (Z)-3-((pyridin-2-yl)methylene)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-((pyridin-2-yl)methylene)indolin-2-one(187325-53-7)
• EPA Substance Registry System: (Z)-3-((pyridin-2-yl)methylene)indolin-2-one(187325-53-7)

Safety Data

• Hazardous Substances Data: 187325-53-7(Hazardous Substances Data)

Usage

Description

(Z)-3-((pyridin-2-yl)methylene)indolin-2-one, a chemical compound with the molecular formula C14H10N2O, belongs to the indolin-2-one family and features a pyridin-2-ylmethylene group. (Z)-3-((pyridin-2-yl)methylene)indolin-2-one is known for its unique structure and potential pharmacological properties, making it a promising candidate for various applications in organic synthesis and medicinal chemistry.

Uses

Used in Organic Synthesis:
(Z)-3-((pyridin-2-yl)methylene)indolin-2-one is used as a building block for the synthesis of other organic compounds, leveraging its unique structure to create a diverse range of chemical products.
Used in Medicinal Chemistry:
(Z)-3-((pyridin-2-yl)methylene)indolin-2-one is used as a starting material for the development of pharmaceutical drugs, taking advantage of its potential pharmacological properties to contribute to the creation of novel therapeutic agents.
Further study and characterization of this compound may reveal additional uses and potential applications in various fields of chemistry and pharmacology, expanding its utility and impact on these industries.

Upstream product

• 91-56-5 indole-2,3-dione 
• 1121-60-4 pyridine-2-carbaldehyde 
• 59-48-3 2-oxoindole 
• 109-06-8 α-picoline 
• 6299-00-9 3-hydroxy-3-<(2-pyridyl)methyl>-1H-indol-2-one 
• 123-75-1 pyrrolidine 

Relevant articles and documents

Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors

Glycogen synthase kinase 3β (GSK-3β) is a widely investigated molecular target for numerous diseases including Alzheimer's disease, cancer, and diabetes mellitus. Inhibition of GSK-3β activity has become an attractive approach for treatment of diabetes and cancer. We report the discovery of novel GSK-3β inhibitors of 3-arylidene-2-oxindole scaffold with promising activity. The most potent compound 3a inhibits GSK-3β with IC50 4.19 nM. In a cell-based assay 3a shows no significant leucocyte toxicity at 10 μM and is moderately cytotoxic against A549 cells. Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization.

Design, synthesis and biological evaluation of oxindole-based chalcones as small-molecule inhibitors of melanogenic tyrosinase

The enzyme tyrosinase regulates melanogenesis and skin hyperpigmentation by converting L-3,4-dihy-droxyphenylalanine (L-DOPA) into dopaquinone, a key step in the melanin biosynthesis. The present work deals with design and synthesis of various oxindole-ba

METHOD OF USING AN INDOLINONE MOLECULE AND DERIVATIVES FOR INHIBITING LIVER FIBROSIS AND HEPATITIS

This invention relates to methods of reversing and inhibiting liver fibrosis and hepatitis using a small indolinone molecule Hesperadin and related compounds. Methods of identifying such agents and using them to inhibit the expression of collagens and ECM