1874-42-6

Basic information

• Product Name: 2-(2-METHOXYPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE
• Synonyms: 2-(2-METHOXYPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE
• CAS NO: 1874-42-6
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.27
• EINECS: 217-501-7
• Mol File: 1874-42-6.mol
• Article Data: 25

Chemical Properties

• Melting Point: 99-101°C
• Boiling Point: 422.4°C at 760 mmHg
• Flash Point: 209.3°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 5.93E-07mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-(2-METHOXYPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHOXYPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(1874-42-6)
• EPA Substance Registry System: 2-(2-METHOXYPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE(1874-42-6)

Safety Data

• Hazardous Substances Data: 1874-42-6(Hazardous Substances Data)

Usage

General Description

2-(2-Methoxyphenyl)-5-phenyl-1,3,4-oxadiazole is a chemical compound with the molecular formula C15H12N2O2. It is an oxadiazole derivative, which is a class of organic compounds with diverse biological activities. This specific compound is known for its potential as a fluorescent probe for detecting metal ions in biological systems. It has also shown promise as a potential anti-inflammatory agent, with research indicating its ability to inhibit the production of inflammatory cytokines. Additionally, 2-(2-Methoxyphenyl)-5-phenyl-1,3,4-oxadiazole has been studied for its potential application as a photosensitizer in the field of photodynamic therapy for cancer treatment. Overall, this compound has garnered interest for its potential pharmacological and biochemical applications.

InChI:InChI=1/C15H12N2O2/c1-18-13-10-6-5-9-12(13)15-17-16-14(19-15)11-7-3-2-4-8-11/h2-10H,1H3

Upstream product

• 7466-54-8 2-methoxybenzoylhydrazine 
• 1663-61-2 triethoxymethylbenzene 
• 6781-63-1 1-benzoyl-2-(2-methoxybenzoyl)hydrazine 
• 86268-08-8 2-methoxy-benzoic acid benzylidenehydrazide 
• 65-85-0 benzoic acid 
• 613-94-5 benzoic acid hydrazide 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 579-75-9 2-Methoxybenzoic acid 
• 71112-99-7 N’-(2-methoxyphenylmethylene)benzohydrazide 
• 98-88-4 benzoyl chloride 
• 135-02-4 ortho-anisaldehyde 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 67-66-3 chloroform 
• 529-28-2 4-iodoanisol 

Downstream Products

• 18233-24-4 2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenol 
• 1642111-06-5 2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenol potassium salt 

Relevant articles and documents

The preparation, characterization and catalytic activity of Ni NPs supported on porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide)

Herein, we report the synthesis of nickel nanoparticles under mild conditions using porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide) as a protecting/stabilizing agent and sodium borohydride as a reducing agent. The porous cross-linked polymeric support was preparedviacombining the use of sol-gel, nanocasting, and crosslinking techniques, in which thep-styrene sulfonamide monomer (PSSA) andN,N′-methylene-bis (acrylamide) (MBA) cross-linker underwent copolymerization on the surface of sodium alginate in the presence of a SiO2nanoparticle (NP) template (Alg-PSSA-co-ACA). The prepared catalyst (Alg-PSSA-co-ACA@Ni) showed high catalytic activity for the one-step synthesis of 1,3,4-oxadiazoles from the reaction of hydrazides and aryl iodides through isocyanide insertion/cyclization.

Efficient green photoluminescence and electroluminescence of iridium complexes with high electron mobility

Aiming to balance the injection and transport of electrons and holes, nitrogen heterocycle and 1,3,4-oxadiazole derivatives were introduced in iridium(iii) complexes to obtain organic light-emitting diodes (OLEDs) with high performances. Thus, two novel Ir(iii) complexes (Ir(tfmphpm)2(pop) and Ir(tfmppm)2(pop)) with green emissions using 2-(3,5-bis(trifluoromethyl)phenyl)pyrimidine (tfmphpm) and 2-(2,6-bis(trifluoromethyl)pyridin-4-yl)pyrimidine (tfmppm) as cyclometalating ligands, and 2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenol (pop) as an ancillary ligand were synthesized. Both emitters show high photoluminescence efficiencies up to 94% and good electron mobility. The devices using two emitters with the structure of ITO (indium-tin-oxide)/MoO3 (molybdenum oxide, 5 nm)/TAPC (di-[4-(N,N-ditolyl-amino)-phenyl]cyclohexane, 30 nm)/mCP (1,3-bis(9H-carbazol-9-yl)benzene, 5 nm)/Ir(iii) complexes (6 wt%):PPO21 (3-(diphenylphosphoryl)-9-(4-(diphenylphosphoryl)phenyl)-9H-carbazole, 10 nm)/TmPyPB (1,3,5-tri(m-pyrid-3-yl-phenyl) benzene, 40 nm)/LiF (1 nm)/Al (100 nm) display good electroluminescence performances with a maximum luminance of 48981 cd m2, a maximum current efficiency of 92.79 cd A1 and a maximum external quantum efficiency up to 31.8%, respectively, and the efficiency roll-off ratio is low, suggesting that they have potential application in OLEDs.

Photocatalyzed facile synthesis of 2,5-diaryl 1,3,4-oxadiazoles with polyaniline-?g-C3N4-TiO2 composite under visible light

PANI (polyaniline)-g-C3N4-TiO2 composite was prepared and found to be efficient for the synthesis of 2,5-diaryl 1,3,4-oxadiazoles under visible light. This reaction involved decarboxylation and cyclization from α-keto acids with acylhydrazines, and a broad scope of substrates were tolerated to provide the desired products in moderate to good yields. Control experiments indicated that a radical pathway was involved in the present photocatalytic reaction and a synergistic effect may exist in the ternary composite. Moreover, this semiconductor photocatalyst could be readily recovered and showed good reusability with only slight decrease in the catalytic activity after six consecutive runs.